The role of cyclodextrins in chiral capillary electrophoresis

Zoltán Juvancz, Rita Bodáné Kendrovics, Róbert Iványi, Lajos Szente

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The members of the enantiomeric pairs frequently show rather different biological effects, so their chiral selective synthesis, pharmacological studies and analysis are necessary. CE has unique advantages in chiral analysis. The most frequently used chiral selectors are CDs in this field. This paper gives a short view on the advantages on CE in direct chiral separations, emphasizing the role of CDs. The reason for the broad selectivity spectra of CDs is discussed in detail. The physical background of chiral selective separations is briefly shown in CE. Their interaction mechanisms are shortly defined. The general trend of their use is statistically evaluated. Most frequently used CDs and CD derivatives are characterized. Advantages of ionizable CDs and single-isomer derivatives are shown. The general trend of their use is established.

Original languageEnglish
Pages (from-to)1701-1712
Number of pages12
JournalELECTROPHORESIS
Volume29
Issue number8
DOIs
Publication statusPublished - Apr 1 2008

Keywords

  • Broad selectivity characters
  • CDs
  • Chiral separations
  • Trends of chiral applications

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'The role of cyclodextrins in chiral capillary electrophoresis'. Together they form a unique fingerprint.

  • Cite this