The role of cognitive dysfunction in the symptoms and remission from depression

Xenia Gonda, Maurizio Pompili, Gianluca Serafini, Andre F. Carvalho, Zoltan Rihmer, Peter Dome

Research output: Contribution to journalReview article

76 Citations (Scopus)


The disability and burden associated with major depression comes only in part from its affective symptoms; cognitive dysfunctions associated with depression also play a crucial role. Furthermore, these cognitive impairments during depression are manifold and multilevel affecting elementary and more complex cognitive processes equally. Several models from different directions tried to evaluate, conceptualize and understand the depth and magnitude of cognitive dysfunctions in depression and their bidirectional interactions with other types of depressive symptomatology including mood symptoms. In the current review, we briefly overview different types of cognitive symptoms and deficits related to major depression including hot and cold as well as trait- and state-like cognitive alterations and we also describe current knowledge related to the impact of cognitive impairments on the course and outcomes of depression including remission, residual symptoms, function, and response to treatment. We also emphasize shortcomings of currently available treatments for depression in sufficiently improving cognitive dysfunctions and point out the need for newer pharmacological approaches especially in cooperation with psychotherapeutic interventions.

Original languageEnglish
Article number27
JournalAnnals of General Psychiatry
Issue number1
Publication statusPublished - Sep 22 2015


  • Cognitive dysfunction
  • Depression
  • Functioning
  • Hot and cold cognitions

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The role of cognitive dysfunction in the symptoms and remission from depression'. Together they form a unique fingerprint.

  • Cite this