The role of co-spray-drying procedure in the preformulation of intranasal propranolol hydrochloride

Rita Ambrus, Matild Gergely, Alenka Zvonar, P. Szabó-Révész, Emese Sipos

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The use of dry powder formulations presents an alternative through which to achieve better deposition and residence time in the nasal cavity, increased stability and possible absorption enhancement. The most important factors involved in the preformulation are particle size and physical stability. Propranolol hydrochloride a model drug was subjected to spray-drying technology to form an intranasal dry powder. Particle size reduction of the drug was carried out by integration (spray-drying) methods, using different excipients. The micrometric properties were characterized by size and morphology. The structure was determined through the use of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy investigations. It was concluded that the intranasal dry powder formulation of propranolol hydrochloride can be achieved with a suitable particle size without polymorph modification or chemical decomposition.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalActa Chimica Slovenica
Volume61
Issue number3
Publication statusPublished - 2014

Fingerprint

Spray drying
Propranolol
Powders
Particle size
Excipients
Polymorphism
Pharmaceutical Preparations
X ray powder diffraction
Differential scanning calorimetry
Decomposition

Keywords

  • Intranasal powder formulation
  • Micronization
  • Propranolol hydrochloride
  • Spray-drying
  • Structural analysis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

The role of co-spray-drying procedure in the preformulation of intranasal propranolol hydrochloride. / Ambrus, Rita; Gergely, Matild; Zvonar, Alenka; Szabó-Révész, P.; Sipos, Emese.

In: Acta Chimica Slovenica, Vol. 61, No. 3, 2014, p. 601-607.

Research output: Contribution to journalArticle

Ambrus, Rita ; Gergely, Matild ; Zvonar, Alenka ; Szabó-Révész, P. ; Sipos, Emese. / The role of co-spray-drying procedure in the preformulation of intranasal propranolol hydrochloride. In: Acta Chimica Slovenica. 2014 ; Vol. 61, No. 3. pp. 601-607.
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