The role of cinchona alkaloids in enantioselective hydrogenation reactions: Are they modifiers or hosts involved in supramolecular heterogeneous catalysis?

József L. Margitfalvi, Emília Tálas, Erno Tfirst, C. V. Kumar, András Gergely

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

In this study experimental evidences are summarized supporting the modifier-substrate interaction taking place in the liquid phase in the enantioselective hydrogenation of α-keto esters and related compounds. The results indicate that the catalytic system cinchona alkaloids-supported platinum (or palladium) can effectively be used in enantioselective hydrogenation for prochiral substrates, in which the prochiral group is part of a conjugated double bond system. It is considered that the above catalytic system is the first example of a new class of heterogeneous catalytic reactions with the involvement of supramolecular catalysis.

Original languageEnglish
Pages (from-to)177-191
Number of pages15
JournalApplied Catalysis A: General
Volume191
Issue number1-2
DOIs
Publication statusPublished - Jan 24 2000

Keywords

  • Cinchona
  • Enantioselective hydrogenation
  • Ethyl pyruvate
  • Supramolecular catalysis

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology

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