In this study experimental evidences are summarized supporting the modifier-substrate interaction taking place in the liquid phase in the enantioselective hydrogenation of α-keto esters and related compounds. The results indicate that the catalytic system cinchona alkaloids-supported platinum (or palladium) can effectively be used in enantioselective hydrogenation for prochiral substrates, in which the prochiral group is part of a conjugated double bond system. It is considered that the above catalytic system is the first example of a new class of heterogeneous catalytic reactions with the involvement of supramolecular catalysis.
- Enantioselective hydrogenation
- Ethyl pyruvate
- Supramolecular catalysis
ASJC Scopus subject areas
- Process Chemistry and Technology