A kromogranin-A és a belole lehasadó WE-14 szerepe az 1-es típusú cukorbetegség kialakulásában

Translated title of the contribution: The role of chromogranin-A and its derived peptide, WE-14 in the development of type 1 diabetes mellitus

Zoltán Herold, P. Nagy, A. Patócs, A. Somogyi

Research output: Contribution to journalArticle

Abstract

Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.

Original languageHungarian
Pages (from-to)163-170
Number of pages8
JournalOrvosi Hetilap
Volume156
Issue number5
DOIs
Publication statusPublished - Feb 1 2015

Fingerprint

Chromogranin A
Type 1 Diabetes Mellitus
Neuroendocrine Cells
Inbred NOD Mouse
Proteins
Transglutaminases
Neuroendocrine Tumors
Autoantigens
Secretory Vesicles
T-Lymphocytes
WE-14 chromogranin A-derived peptide
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A kromogranin-A és a belole lehasadó WE-14 szerepe az 1-es típusú cukorbetegség kialakulásában. / Herold, Zoltán; Nagy, P.; Patócs, A.; Somogyi, A.

In: Orvosi Hetilap, Vol. 156, No. 5, 01.02.2015, p. 163-170.

Research output: Contribution to journalArticle

@article{f011e688e7424de891524abfc2201b76,
title = "A kromogranin-A {\'e}s a belole lehasad{\'o} WE-14 szerepe az 1-es t{\'i}pus{\'u} cukorbetegs{\'e}g kialakul{\'a}s{\'a}ban",
abstract = "Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.",
keywords = "chromogranin-A, diabetes mellitus, diabetes mellitus, kromogranin-A, tumormarker, tumour marker, WE-14, WE-14",
author = "Zolt{\'a}n Herold and P. Nagy and A. Pat{\'o}cs and A. Somogyi",
year = "2015",
month = "2",
day = "1",
doi = "10.1556/OH.2015.30087",
language = "Hungarian",
volume = "156",
pages = "163--170",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "5",

}

TY - JOUR

T1 - A kromogranin-A és a belole lehasadó WE-14 szerepe az 1-es típusú cukorbetegség kialakulásában

AU - Herold, Zoltán

AU - Nagy, P.

AU - Patócs, A.

AU - Somogyi, A.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.

AB - Chromogranin-A is a member of the granine protein family. It is produced in neuroendocrine cells via secretory granules. Many cleavage proteins are formed from chromogranin-A, from which some have well known biological activity, while the function of others is not yet fully known. Serum chromogranin-A levels are used in neuroendocrine tumour diagnostics. Recent studies showed that one of its cleavage protein, WE-14 may also play a role in the development of type 1 diabetes. WE-14 may function as an autoantigen for T-cells involved in the destruction of β-cells. This mechanism was previously observed only in non-obese diabetic mice. Novel results show that WE-14 also serves as a target for autoreactive cells in newly diagnosed type 1 diabetic patients as well, which reaction can be increased with transglutaminase. In this paper the authors summarize the recent knowledge about chromogranin-A and its potential role in the pathomechanism of type 1 diabetes mellitus.

KW - chromogranin-A

KW - diabetes mellitus

KW - diabetes mellitus

KW - kromogranin-A

KW - tumormarker

KW - tumour marker

KW - WE-14

KW - WE-14

UR - http://www.scopus.com/inward/record.url?scp=84921783024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921783024&partnerID=8YFLogxK

U2 - 10.1556/OH.2015.30087

DO - 10.1556/OH.2015.30087

M3 - Article

VL - 156

SP - 163

EP - 170

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 5

ER -