A caveolin-1 gén szerepe a carcinogenesisben.

Translated title of the contribution: The role of caveolin-1 gene in carcinogenesis

Márk Juhász, Márton Vértesaljai, László Herszényi, Peter Malfertheiner, Matthias P.A. Ebert, Zsolt Tulassay

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Caveolin-1 is responsible for the development of caveolae, which are vesicular invaginations of the plasma membrane, and plays a key role in membrane traffic and signal transduction. The role of caveolin-1 in carcinogenesis has been a subject to numerous investigations, however, the expression pattern and the function of caveolin-1 are rather controversial both in gastrointestinal and extraintestinal cancers. The vast majority of results based on cancer cell line experiments indicate that caveolin-1 might act as a tumor suppressor gene. In tumor tissues, however, caveolin-1 seem to fulfill a tumor promoting role, since the expression of caveolin-1 is increased when compared to normal tissue counterparts. In this review, the authors summarize the results of caveolin-1 expression in gastrointestinal and extraintestinal cancer emphasizing possible future therapeutic implications.

Translated title of the contributionThe role of caveolin-1 gene in carcinogenesis
Original languageHungarian
Pages (from-to)1985-1989
Number of pages5
JournalOrvosi hetilap
Volume145
Issue number39
Publication statusPublished - Sep 26 2004

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Juhász, M., Vértesaljai, M., Herszényi, L., Malfertheiner, P., Ebert, M. P. A., & Tulassay, Z. (2004). A caveolin-1 gén szerepe a carcinogenesisben. Orvosi hetilap, 145(39), 1985-1989.