The role of catecholamines in the prolactin release induced by salsolinol

D. Székács, I. Bodnár, E. S. Vizi, G. M. Nagy, M. I.K. Fekete

Research output: Contribution to journalArticle

14 Citations (Scopus)


Salsolinol (1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline) is an endogenous prolactin releasing agent. Its action can be inhibited by another isoquinoline, 1-methyl-3,4-dihydroisoquinoline (1MeDIQ), which has a strong norepinephrine releasing activity. Salsolinol does not alter the dopamine release in median eminence in vitro, providing evidence for the lack of interaction with presynaptic D2 dopamine receptors. At the same time, lack of norepinephrine transporter abolishes salsolinol's action. Salsolinol decreases tissue level of dopamine and increases norepinephrine to dopamine ratio in organs innervated by the sympathetic nervous system indicating a possible decrease of norepinephrine release. Enzymes of catecholamine synthesis and metabolism are probably also not the site of action of salsolinol. In summary, based upon all of these observations a physiologically relevant interplay might exist between the sympatho-neuronal system and the regulation of prolactin release.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalNeurochemistry international
Issue number5
Publication statusPublished - Oct 1 2007


  • Dopamine
  • Norepinephrine
  • Prolactin
  • Salsolinol

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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