The role of Ca2+ in hormonal imprinting of the Tetrahymena.

P. Kovács, G. Csaba

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

It is known from model experiments on Tetrahymena that primary exposure to a hormone induces receptor formation or amplification, in other words a hormonal imprinting. Substances acting on the intracellular Ca2+ level of the Tetrahymena, such as TMB-8, EDTA, EGTA, NiCl2 and La(NO3)3, interfered with hormonal imprinting of the unicellular to different degrees, and some of them influenced hormone (insulin, TSH) binding also independently of imprinting. Interference with the intracellular Ca-metabolism generally influenced imprinting by insulin and TSH, which were mediated by different mechanisms, to dissimilar degrees, or in opposite directions. On combined application of the agents acting on Ca-metabolism, their effects were additive. It appears that intact Ca-mediation is an essential prerequisite for normal hormonal imprinting.

Original languageEnglish
Pages (from-to)167-179
Number of pages13
JournalActa Physiologica Hungarica
Volume69
Issue number2
Publication statusPublished - 1987

Fingerprint

Tetrahymena
Hormones
Insulin
Egtazic Acid
Edetic Acid
Direction compound
8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate

ASJC Scopus subject areas

  • Physiology

Cite this

The role of Ca2+ in hormonal imprinting of the Tetrahymena. / Kovács, P.; Csaba, G.

In: Acta Physiologica Hungarica, Vol. 69, No. 2, 1987, p. 167-179.

Research output: Contribution to journalArticle

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