A biológiai szerek szerepe a psoriasis gyógykezelésében 9 randomizált, placebokontrollált vizsgálat eredményei alapján

Translated title of the contribution: The role of biological drugs in the treatment of psoriasis, results from 9 randomized placebo-controlled trials

Lajos Kemény, Valentin Brodszky, Krisztán Kárpáti, László Gulácsi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Recognition the key role of TNF-α in the pathogenesis of psoriasis makes possible to use new and efficacious drugs in the treatment. In the years past more trials were published, which are examining the efficacy of different biological drugs. There is no analysis which is including all the trials with biological drugs. Objective: The authors compared the efficacy of biological drugs - efalizumab, etanercept, infliximab - in the treatment of psoriasis. The evidences on effect of biological drugs were synthesized. The safety of drugs also was examined. Methods: The authors searched the MEDLINE database for all trials with TNF-α in the treatment of psoriasis. The authors conducted a meta-analysis with the results of trials. The random effect model were used for the data synthesis, the results were probed with Mantel-Haenszel test. Results: Data were combined from 13 trials included 4165 patients. All the three examined biological drugs are significantly superior to placebo treatment in improving the symptoms of psoriasis. Data from 3 trials included 1242 patients prove, that using 1 mg/kg etanercept the proportion of patients whom skin response improved at least 75% is greater with 25% than using placebo (RD = 0.25 95% Cl 0.21-0.29). Data from 5 trials included 995 patients show, that using 2 × 25 mg etanercept the proportion of patients whom skin response improved at least 75% is greater with 29% than using placebo (RD = 0.29 95% Cl 0.24-0.33). Data from 5 trials included 759 patients prove, that using 5 mg/kg infliximab the proportion of patients whom skin response improved at least 75% is greater with 73% than using placebo (RD = 0.73 95% Cl 0.68-0.78). Biological treatment of 3 patients improves 1 patient's skin-symptoms at least with 75% (NNT = 2.7 95% Cl 2.6-2.9). Condusions: According to the available data the TNF-α inhibitors are effective in improving the symptoms of psoriasis non-responding to the conventional treatment. After the meta-analysis of data infliximab seems to be the most effective biological treatment.

Original languageHungarian
Pages (from-to)981-990
Number of pages10
JournalOrvosi hetilap
Volume147
Issue number21
Publication statusPublished - May 28 2006

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ASJC Scopus subject areas

  • Medicine(all)

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