The role of biglycan in the heart

Erika Bereczki, M. Sántha

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Biglycan, a member of the small leucine rich proteoglycan family, is known to be expressed in almost every tissue of our body. Although there are increasing amount of data on the biological role of biglycan, its cardiac function is still not totally clarified. Cardiac protein profiling of biglycan transgenic mice and other studies revealed its involvement in heart failure, myocardial remodeling, and a possible role in promoting cardioprotection. The localization of biglycan on the cell surface and its "pericellular" arrangement as well as the presence of reactive GAG chains on its surface suggest an involvement in transmission of extracellular signals to intracellular signaling molecules and a role in regulation of Ca++ trafficking. In this review, the role of biglycan in the heart under normal physiological as well as pathological conditions is summarized and critically discussed.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalConnective Tissue Research
Volume49
Issue number3-4
DOIs
Publication statusPublished - May 2008

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Biglycan
Proteoglycans
Leucine
Transgenic Mice
Heart Failure
Tissue
Molecules
Proteins

Keywords

  • Atherosclerosis
  • Biglycan
  • Cardiac Remodeling
  • Cell Signaling
  • Heart Failure

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Nephrology
  • Cell Biology
  • Orthopedics and Sports Medicine

Cite this

The role of biglycan in the heart. / Bereczki, Erika; Sántha, M.

In: Connective Tissue Research, Vol. 49, No. 3-4, 05.2008, p. 129-132.

Research output: Contribution to journalArticle

Bereczki, Erika ; Sántha, M. / The role of biglycan in the heart. In: Connective Tissue Research. 2008 ; Vol. 49, No. 3-4. pp. 129-132.
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