The role of bacterial toxins in Sudden Infant Death Syndrome (SIDS)

C. C. Blackwell, A. E. Gordon, V. S. James, D. A.C. MacKenzie, M. Mogensen-Buchanan, O. R. El Ahmer, O. M. Al Madani, K. Törö, Z. Csukás, P. Sótonyi, D. M. Weir, A. Busuttil

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52 Citations (Scopus)

Abstract

There is increasing evidence for the involvement of bacterial toxins in some cases of Sudden Infant Death Syndrome (SIDS), particularly the pyrogenic toxins of Staphylococcus aureus. This had led to the hypothesis that some SIDS deaths are due to induction of inflammatory mediators by infectious agents or their products during a period in which the infant is unable to control these normally protective responses. The genetic, developmental and environmental risk factors identified for SIDS are assessed in relation to frequency or density of mucosal colonisation by toxigenic bacteria and their effects on induction and control of inflammatory responses to the toxins.

Original languageEnglish
Pages (from-to)561-570
Number of pages10
JournalInternational Journal of Medical Microbiology
Volume291
Issue number6-7
DOIs
Publication statusPublished - Jan 1 2001

Keywords

  • Bacterial toxins
  • Cigarette smoke
  • Inflammation
  • Risk factors
  • Staphylococcus aureus
  • Sudden Infant Death Syndrome

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Blackwell, C. C., Gordon, A. E., James, V. S., MacKenzie, D. A. C., Mogensen-Buchanan, M., El Ahmer, O. R., Al Madani, O. M., Törö, K., Csukás, Z., Sótonyi, P., Weir, D. M., & Busuttil, A. (2001). The role of bacterial toxins in Sudden Infant Death Syndrome (SIDS). International Journal of Medical Microbiology, 291(6-7), 561-570. https://doi.org/10.1078/1438-4221-00168