The active, programmed cell death (apoptosis) plays a decisive role in numerous physiological and pathological processes. Investigations in the last decade pointed out the fact, that apoptosis can be defected and may be considered as initiating and regulating factor in the development, senescence and also in numerous diseases of the central nervous system. Beyond experimental data importance is attributed to neuronal apoptosis in Parkinson's disease, Alzheimer's disease, Huntington's disease, Friedreich's ataxia, Down's disease, AIDS and even in schizophrenia. The so-called necrobiotic zone, consisting of apoptotic cells around large necroses of the central nervous system, should also be taken into consideration. All these facts made clear that anti-apoptotic therapy of the above mentioned conditions is planned to be introduced. Inhibitors of caspase-3-key-enzyme in the process of apoptosis - such as the X-linked Inhibitor of Apoptosis (XIAP), have to be mentioned on the first place, in this respect. (-)-deprenyl, a compound with mitochondrial membrane-stabilizing capacity is also a promising drug against neurodegenerative diseases. (-)-deprenyl is a medicine developed by Hungarian scientists and Hungarian research workers are playing important role in the investigation of the mode of action of this compound.
|Translated title of the contribution||The role of apoptosis in the central nervous system|
|Number of pages||5|
|Publication status||Published - Dec 1 2002|
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