Antitestek szerepe Graves-ophthalmopathiában.

Translated title of the contribution: The role of antibodies in Graves' ophthalmopathy

I. Molnár, C. Balázs

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the possible pathogenetic role of autoantibodies to eye muscle membrane fractions in 75 patients with Graves' disease (50 patients with infiltrative ophthalmopathy). Autoantibodies directed to four fractions of human eye muscle--as well as thyroid membranes prepared by ultracentrifugation were detected by ELISA and Western blotting techniques. None of autoantibodies to various fractions of eye muscle membrane proved to be specific for Graves' ophthalmopathy, however, the presence of these antibodies and activity of eye symptoms were in correlation. Polyclonal autoantibodies to common epitopes on both thyroid and eye muscle membrane antigens (approximately 60 kD) were revealed that might be involved into pathogenesis of Graves' ophthalmopathy.

Original languageHungarian
Pages (from-to)2097-2100
Number of pages4
JournalOrvosi Hetilap
Volume132
Issue number38
Publication statusPublished - Sep 22 1991

Fingerprint

Graves Ophthalmopathy
Autoantibodies
Antibodies
Muscles
Membranes
Thyroid Gland
Ultracentrifugation
Graves Disease
Epitopes
Western Blotting
Enzyme-Linked Immunosorbent Assay
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Antitestek szerepe Graves-ophthalmopathiában. / Molnár, I.; Balázs, C.

In: Orvosi Hetilap, Vol. 132, No. 38, 22.09.1991, p. 2097-2100.

Research output: Contribution to journalArticle

Molnár, I & Balázs, C 1991, 'Antitestek szerepe Graves-ophthalmopathiában.', Orvosi Hetilap, vol. 132, no. 38, pp. 2097-2100.
Molnár, I. ; Balázs, C. / Antitestek szerepe Graves-ophthalmopathiában. In: Orvosi Hetilap. 1991 ; Vol. 132, No. 38. pp. 2097-2100.
@article{3f696d46096d48109dbae7952f63e32d,
title = "Antitestek szerepe Graves-ophthalmopathi{\'a}ban.",
abstract = "The aim of this study was to investigate the possible pathogenetic role of autoantibodies to eye muscle membrane fractions in 75 patients with Graves' disease (50 patients with infiltrative ophthalmopathy). Autoantibodies directed to four fractions of human eye muscle--as well as thyroid membranes prepared by ultracentrifugation were detected by ELISA and Western blotting techniques. None of autoantibodies to various fractions of eye muscle membrane proved to be specific for Graves' ophthalmopathy, however, the presence of these antibodies and activity of eye symptoms were in correlation. Polyclonal autoantibodies to common epitopes on both thyroid and eye muscle membrane antigens (approximately 60 kD) were revealed that might be involved into pathogenesis of Graves' ophthalmopathy.",
author = "I. Moln{\'a}r and C. Bal{\'a}zs",
year = "1991",
month = "9",
day = "22",
language = "Hungarian",
volume = "132",
pages = "2097--2100",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "38",

}

TY - JOUR

T1 - Antitestek szerepe Graves-ophthalmopathiában.

AU - Molnár, I.

AU - Balázs, C.

PY - 1991/9/22

Y1 - 1991/9/22

N2 - The aim of this study was to investigate the possible pathogenetic role of autoantibodies to eye muscle membrane fractions in 75 patients with Graves' disease (50 patients with infiltrative ophthalmopathy). Autoantibodies directed to four fractions of human eye muscle--as well as thyroid membranes prepared by ultracentrifugation were detected by ELISA and Western blotting techniques. None of autoantibodies to various fractions of eye muscle membrane proved to be specific for Graves' ophthalmopathy, however, the presence of these antibodies and activity of eye symptoms were in correlation. Polyclonal autoantibodies to common epitopes on both thyroid and eye muscle membrane antigens (approximately 60 kD) were revealed that might be involved into pathogenesis of Graves' ophthalmopathy.

AB - The aim of this study was to investigate the possible pathogenetic role of autoantibodies to eye muscle membrane fractions in 75 patients with Graves' disease (50 patients with infiltrative ophthalmopathy). Autoantibodies directed to four fractions of human eye muscle--as well as thyroid membranes prepared by ultracentrifugation were detected by ELISA and Western blotting techniques. None of autoantibodies to various fractions of eye muscle membrane proved to be specific for Graves' ophthalmopathy, however, the presence of these antibodies and activity of eye symptoms were in correlation. Polyclonal autoantibodies to common epitopes on both thyroid and eye muscle membrane antigens (approximately 60 kD) were revealed that might be involved into pathogenesis of Graves' ophthalmopathy.

UR - http://www.scopus.com/inward/record.url?scp=0026430011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026430011&partnerID=8YFLogxK

M3 - Article

C2 - 1923482

AN - SCOPUS:0026430011

VL - 132

SP - 2097

EP - 2100

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 38

ER -