The role of γ/δ T cell receptor positive cells in pregnancy

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

PROBLEM: Due to the lack of classical HLA antigens on the trophoblast, fetal antigens are possibly presented in a non major histocompatibility complex (MHC) restricted way. Decidual γδ T cells, which significantly increase in number during pregnancy, might play a role in recognition of fetal antigens and also in determining the quality of the response to these antigens. Our study was aimed at investigating the role of this cell population in progesterone-dependent immunomodulation. METHOD OF STUDY: Peripheral lymphocytes from healthy pregnant women and from habitual aborters were tested by immunocytochemistry for the presence of γ/δ T cell receptor (TCR) and progesterone receptor. To investigate the effect of treatment with a pan anti γ/δ antibody, lymphocytes were incubated for 3 hr with the antibody, and then interleukin (IL)-10, IL-12 and progesterone-induced blocking factor (PIBF) expression (by immuno-cytochemistry) as well as natural killer (NK) cell activity were determined. RESULTS: In peripheral blood of healthy pregnant women the percentage of γ/δ TCR+ cells was significantly higher (P <0.001) than in that of recurrent aborters or of non-pregnant individuals. Ninety-seven percent of γ/δ TCR+ pregnancy lymphocytes expressed progesterone receptor. Binding of a specific antibody to the γ/δ TCR inhibited PIBF- as well as IL-10 production, whereas it increased NK activily and IL-12 expression. CONCLUSIONS: These data suggest the role of γ/δ TCR-bearing lymphocytes in progesterone-dependent immunomodulation.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume41
Issue number4
Publication statusPublished - Apr 1999

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T-Cell Antigen Receptor
Progesterone
Pregnancy
Lymphocytes
Immunomodulation
Progesterone Receptors
Interleukin-12
Antigens
Interleukin-10
Pregnant Women
Histocytochemistry
Antibodies
Trophoblasts
HLA Antigens
Major Histocompatibility Complex
Natural Killer Cells
Anti-Idiotypic Antibodies
Immunohistochemistry
T-Lymphocytes
Population

Keywords

  • γ/δ TCR
  • NK activity
  • Progesterone

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

The role of γ/δ T cell receptor positive cells in pregnancy. / Polgár, B.; Barakonyi, A.; Xynos, I.; Szekeres-Barthó, J.

In: American Journal of Reproductive Immunology, Vol. 41, No. 4, 04.1999, p. 239-244.

Research output: Contribution to journalArticle

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