The revascularization syndrome of the lower limbs

E. Arató, M. Kürthy, G. Jancsó, G. Kasza, I. Rozsos, H. Merkli, E. Pál, L. Kollár, E. Roth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Today the vascular surgical recanalization of acutely occluded arteries is practically worked out, but sometimes we have to pay a huge price for the restitution of circulation. During ischemia and reperfusion, a chain of cascade-like pathophysiological processes starts that eventually leads to cell death, threatening the integrity of the whole organism. Amazingly, the cells still alive can further be damaged and the so-called »oxygen paradox« shall arise during which the oxygen free radicals play an important role. The authors examine this range of questions causing important diagnostic and therapeutic problems from manifold aspects. The investigations included the photo- and electron microscopic analysis of the ischemic striated muscle, the changes of the protective systems of free radicals and antioxidants during ischemia and reperfusion, as well as the follow-up of the CD11a and CD18 cell surface adhesive molecules playing a key role in the development of systemic effects of the revascularization syndrome. To eliminate subjective elements during indication of fasciotomy, the direct pressure measurement of tibial anterior compartment is performed. The authors expect that, besides the classical biochemical monitoring, the above manifold approach will make it easier to understand the process and its therapeutic benefits will appear in the results as well.

Original languageEnglish
Pages (from-to)168-176
Number of pages9
JournalPerfusion
Volume18
Issue number5
Publication statusPublished - May 1 2005

Keywords

  • Compartment syndrome
  • Critical extremital ischemia
  • Oxygen free radicals
  • Reperfusion impairment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Arató, E., Kürthy, M., Jancsó, G., Kasza, G., Rozsos, I., Merkli, H., Pál, E., Kollár, L., & Roth, E. (2005). The revascularization syndrome of the lower limbs. Perfusion, 18(5), 168-176.