LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG

Translated title of the contribution: The results of liver biopsies during rifampicin therapy

D. Kozma, K. Lapis, A. Tompa

Research output: Contribution to journalArticle

Abstract

The effects of rifampicin on the liver were studied by means of biopsies in 10 persons who had rifampicin therapy. The biopsy was repeated in 3 cases. Treatment with a combination of rifampicin and ethambutol caused degenerative changes in the liver of varying degree. The electron microscopic picture was characterized by proliferation of the endplasmatic reticulum, hyperplasia of the Golgi apparatus and the appearance of lipofuscin granules. The changes observed during rifampicin cum ethambutol treatment were comparatively slight and were related to the breakdown of the drug. They did not indicate a direct effect of rifampicin on the liver cells.

Translated title of the contributionThe results of liver biopsies during rifampicin therapy
Original languageGerman
Pages (from-to)764-770
Number of pages7
JournalPRAX.PNEUMOL.
Volume30
Issue number12
Publication statusPublished - Jan 1 1976

ASJC Scopus subject areas

  • Medicine(all)

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