LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG

Translated title of the contribution: The results of liver biopsies during rifampicin therapy

D. Kozma, K. Lapis, A. Tompa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The effects of rifampicin on the liver were studied by means of biopsies in 10 persons who had rifampicin therapy. The biopsy was repeated in 3 cases. Treatment with a combination of rifampicin and ethambutol caused degenerative changes in the liver of varying degree. The electron microscopic picture was characterized by proliferation of the endplasmatic reticulum, hyperplasia of the Golgi apparatus and the appearance of lipofuscin granules. The changes observed during rifampicin cum ethambutol treatment were comparatively slight and were related to the breakdown of the drug. They did not indicate a direct effect of rifampicin on the liver cells.

Original languageGerman
Title of host publicationPRAX.PNEUMOL.
Pages764-770
Number of pages7
Volume30
Edition12
Publication statusPublished - 1976

Fingerprint

Rifampin
Biopsy
Liver
Ethambutol
Therapeutics
Lipofuscin
Reticulum
Golgi Apparatus
Hyperplasia
Electrons
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kozma, D., Lapis, K., & Tompa, A. (1976). LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG. In PRAX.PNEUMOL. (12 ed., Vol. 30, pp. 764-770)

LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG. / Kozma, D.; Lapis, K.; Tompa, A.

PRAX.PNEUMOL.. Vol. 30 12. ed. 1976. p. 764-770.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kozma, D, Lapis, K & Tompa, A 1976, LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG. in PRAX.PNEUMOL.. 12 edn, vol. 30, pp. 764-770.
Kozma D, Lapis K, Tompa A. LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG. In PRAX.PNEUMOL.. 12 ed. Vol. 30. 1976. p. 764-770
Kozma, D. ; Lapis, K. ; Tompa, A. / LEBERBIOPSIE WAHREND DER RIFAMPICIN BEHANDLUNG. PRAX.PNEUMOL.. Vol. 30 12. ed. 1976. pp. 764-770
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