The effects of rifampicin on the liver were studied by means of biopsies in 10 persons who had rifampicin therapy. The biopsy was repeated in 3 cases. Treatment with a combination of rifampicin and ethambutol caused degenerative changes in the liver of varying degree. The electron microscopic picture was characterized by proliferation of the endplasmatic reticulum, hyperplasia of the Golgi apparatus and the appearance of lipofuscin granules. The changes observed during rifampicin cum ethambutol treatment were comparatively slight and were related to the breakdown of the drug. They did not indicate a direct effect of rifampicin on the liver cells.
|Translated title of the contribution||The results of liver biopsies during rifampicin therapy|
|Number of pages||7|
|Publication status||Published - Jan 1 1976|
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