The relevance of neck linker docking in the motility of kinesin

András Czövek, Gergely J. Szöllosi, Imre Derényi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Conventional kinesin is a motor protein, which is able to walk along a microtubule processively. The exact mechanism of the stepping motion and force generation of kinesin is still far from clear. In this paper we argue that neck linker docking is a crucial element of this mechanism, without which the experimentally observed dwell times of the steps could not be explained under a wide range of loading forces. We also show that the experimental data impose very strict constraints on the lengths of both the neck linker and its docking section, which are compatible with the known structure of kinesin.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalBioSystems
Volume93
Issue number1-2
DOIs
Publication statusPublished - Jul 1 2008

Keywords

  • Entropic spring
  • Free energy
  • Kinesin
  • Neck linker

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics

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