The release of prostanoids during the acute pulmonary response to E. coli endotoxin in anaesthetized cats

S. J. Coker, B. Hughes, J. Parratt, I. W. Rodger, I. J. Zeitlin

Research output: Contribution to journalArticle

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Abstract

The administration of E. coli endotoxin (2 mg/kg i.v.) to anaesthetized cats in a characteristic acute pulmonary response. This consists of increases in pulmonary artery pressure and airways resistance and a reduction in lung compliance. Plasma concentrations of prostaglandin E 2 (PGE 2), PGF 2(α), thromboxane B 2 and 6-keto PGF 1(α) were measured by radioimmunoassay in aortic and pulmonary arterial blood samples before, during and after the acute pulmonary response to endotoxin. Endotoxin administration resulted in the rapid release of PGF 2(α) and thromboxane B 2 from the lungs. The time course of this release was parallel to that of the pulmonary hypertensive and airways responses to endotoxin. PGE 2 and 6-keto PGF 1(α) were released more gradually and with greater variations between individual animals. During the delayed shock phase (2 h after endotoxin) the concentrations of PGE 2, PGF 2(α) and 6-keto PGF 1(α) were once again elevated in both the aorta and pulmonary artery. Thromboxane B 2 concentrations were not increased at this time. These results suggest that PGF 2(α) and thromboxane A 2 may be mediators of the acute pulmonary responses to endotoxin.

Original languageEnglish
Pages (from-to)561-570
Number of pages10
JournalBritish Journal of Pharmacology
Volume78
Issue number3
Publication statusPublished - 1983

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Prostaglandins F
Endotoxins
Prostaglandins
Cats
Escherichia coli
Thromboxanes
Lung
Prostaglandins E
Pulmonary Artery
Lung Compliance
Airway Resistance
varespladib methyl
Radioimmunoassay
Aorta
Shock
Pressure

ASJC Scopus subject areas

  • Pharmacology

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The release of prostanoids during the acute pulmonary response to E. coli endotoxin in anaesthetized cats. / Coker, S. J.; Hughes, B.; Parratt, J.; Rodger, I. W.; Zeitlin, I. J.

In: British Journal of Pharmacology, Vol. 78, No. 3, 1983, p. 561-570.

Research output: Contribution to journalArticle

Coker, S. J. ; Hughes, B. ; Parratt, J. ; Rodger, I. W. ; Zeitlin, I. J. / The release of prostanoids during the acute pulmonary response to E. coli endotoxin in anaesthetized cats. In: British Journal of Pharmacology. 1983 ; Vol. 78, No. 3. pp. 561-570.
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