The release of an ampholytic drug from acrylic films

M. Dittgen, B. Noszal, G. Stampf

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Benzyloxiamine was used as an ampholytic drug model to study the in vitro drug release from films in a function of pH. Two films based on commercial acrylic dispersions ScopacrylR and EudragitR were used as drug carriers. The films investigated were produced by a solvent east technique. The pH into the films was adjusted at every experiment before cast To understand the factors governing the release of the ampholytic drug its protonation/ionization macro and microconstants have been determined. The protonation macroconatants determined were log K1= 7.80, log K2 = 4.26 and log B2= 12.06. The microconstants calculated were log Kf= 7.79, log Ka= 4.74, log Kaf = 7.33 and log Kfa = 4.29. The release data could be interpreted by taking into account species concentrations calculated by use these constants on the one hand and the velocity and diffusion coefficients on the other.

Original languageEnglish
Pages (from-to)1663-1674
Number of pages12
JournalDrug development and industrial pharmacy
Volume12
Issue number11-13
DOIs
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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