The relationship between sister chromatid exchange induction and leukemogenicity of different cytostatics.

T. Raposa, J. Várkonyi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The genotoxicity of frequently used cytostatic agents was characterized by the enumeration of the sister chromatid exchanges (SCEs) induced by them in vivo in phytohemagglutinin-stimulated peripheral blood lymphocytes. Fifty-nine cancer patients undergoing and off chemotherapy are included in this study. The aim was to identify cytostatics according to their ability to alter the SCE frequency. Cytostatics with strong SCE-inducing ability (melphalan, cyclophosphamide, cyclophosphamide + vincristine + 5-fluorouracil, cyclophosphamide + vincristine + procarbazid + prednisolone) usually exhibited a longlasting SCE elevation. Cytosine arabinoside, hydroxyurea, vincristine, 5-fluorouracil, tamoxifen, and azathioprine did not induce SCEs. These data were compared with the leukemogenic potential of the same drugs in order to validate the relevance of SCE studies in man to signal carcinogenic hazards. It was found that over 80% of all secondary leukemias (collected from the world literature from 1930 to 1980) were preceded by the administration of cytotoxic compounds inducing long-lasting SCE elevation in lymphocytes. Only 3% of all secondary leukemias can be attributed to drugs not inducing SCEs in vivo in PHA-stimulated lymphocytes. This indicates that the lesions important for SCEs and secondary leukemias to emerge bear close biological similarities. Thus SCE studies can be used in selecting therapeutical protocols or new cytostatics with less carcinogenic potential to man.

Original languageEnglish
Pages (from-to)141-151
Number of pages11
JournalCancer Detection and Prevention
Volume10
Issue number1-2
Publication statusPublished - 1987

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Sister Chromatid Exchange
Cytostatic Agents
Vincristine
Cyclophosphamide
Leukemia
Lymphocytes
Fluorouracil
Melphalan
Hydroxyurea
Cytarabine
Azathioprine
Phytohemagglutinins
Tamoxifen
Prednisolone
Pharmaceutical Preparations
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The relationship between sister chromatid exchange induction and leukemogenicity of different cytostatics. / Raposa, T.; Várkonyi, J.

In: Cancer Detection and Prevention, Vol. 10, No. 1-2, 1987, p. 141-151.

Research output: Contribution to journalArticle

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