The relationship between carnitine and ketone body levels in diabetic children

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Free carnitine was significantly (p <0.001) reduced both in the ketotic (29.7 ± 3.4 nmol/ml) and in the ketoacidotic (24.6 ± 1.4 nmol/ml) groups when compared to controls (50.0 ± 2.4 nmol/ml). At the same time, acylcarnitine values in the ketotic (21.2 ± 2.4 nmol/ml) and ketoacidotic (25.4 ± 2.3 nmol/ml) groups were significantly above the control value (4.71 ± 0.6 nmol/ml). There was no significant difference between the two ketotic groups in carnitine derivatives. The abnormal distribution of plasma free and acylcarnitines could be reversed by insulin treatment. There was an inverse correlation between ketone body levels and free carnitine in the ketotic (r = -0.71, p <0.02) and ketoacidotic group (r = -0.71, p <0.05). However, there was no correlation between ketone bodies and acylcarnitine and between free carnitine and acylcarnitines. We concluded that the increased acylation was only partly responsible for the reduction of free carnitine in diabetic ketosis.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalActa Paediatrica Scandinavica
Volume72
Issue number4
Publication statusPublished - 1983

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Ketone Bodies
Carnitine
Diabetic Ketoacidosis
Acylation
Insulin
acylcarnitine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The relationship between carnitine and ketone body levels in diabetic children. / Soltész, G.; Melegh, B.; Sandor, A.

In: Acta Paediatrica Scandinavica, Vol. 72, No. 4, 1983, p. 511-515.

Research output: Contribution to journalArticle

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N2 - Free carnitine was significantly (p <0.001) reduced both in the ketotic (29.7 ± 3.4 nmol/ml) and in the ketoacidotic (24.6 ± 1.4 nmol/ml) groups when compared to controls (50.0 ± 2.4 nmol/ml). At the same time, acylcarnitine values in the ketotic (21.2 ± 2.4 nmol/ml) and ketoacidotic (25.4 ± 2.3 nmol/ml) groups were significantly above the control value (4.71 ± 0.6 nmol/ml). There was no significant difference between the two ketotic groups in carnitine derivatives. The abnormal distribution of plasma free and acylcarnitines could be reversed by insulin treatment. There was an inverse correlation between ketone body levels and free carnitine in the ketotic (r = -0.71, p <0.02) and ketoacidotic group (r = -0.71, p <0.05). However, there was no correlation between ketone bodies and acylcarnitine and between free carnitine and acylcarnitines. We concluded that the increased acylation was only partly responsible for the reduction of free carnitine in diabetic ketosis.

AB - Free carnitine was significantly (p <0.001) reduced both in the ketotic (29.7 ± 3.4 nmol/ml) and in the ketoacidotic (24.6 ± 1.4 nmol/ml) groups when compared to controls (50.0 ± 2.4 nmol/ml). At the same time, acylcarnitine values in the ketotic (21.2 ± 2.4 nmol/ml) and ketoacidotic (25.4 ± 2.3 nmol/ml) groups were significantly above the control value (4.71 ± 0.6 nmol/ml). There was no significant difference between the two ketotic groups in carnitine derivatives. The abnormal distribution of plasma free and acylcarnitines could be reversed by insulin treatment. There was an inverse correlation between ketone body levels and free carnitine in the ketotic (r = -0.71, p <0.02) and ketoacidotic group (r = -0.71, p <0.05). However, there was no correlation between ketone bodies and acylcarnitine and between free carnitine and acylcarnitines. We concluded that the increased acylation was only partly responsible for the reduction of free carnitine in diabetic ketosis.

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