The regulation of aging: does autophagy underlie longevity?

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Abstract

The accumulation of cellular damage is a feature common to all aging cells and leads to decreased ability of the organism to survive. The overall rate at which damage accumulates is influenced by conserved metabolic factors (longevity pathways and regulatory proteins) that control lifespan through adjusting mechanisms for maintenance and repair. Autophagy, the major catabolic process of eukaryotic cells that degrades and recycles damaged macromolecules and organelles, is implicated in aging and in the incidence of diverse age-related pathologies. Recent evidence has revealed that autophagic activity is required for lifespan extension in various long-lived mutant organisms, and that numerous autophagy-related genes or proteins are directly regulated by longevity pathways. These findings support the emerging view that autophagy is a central regulatory mechanism for aging in diverse eukaryotic species.

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalTrends in Cell Biology
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 1 2009

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ASJC Scopus subject areas

  • Cell Biology

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