Anyai szövodmények elofordulása 107 HELLP-szindrómával szövodött terhesség kapcsán

Translated title of the contribution: The rate of maternal complications in 107 pregnancies complicated with HELLP syndrome

P. Hupuczi, I. Sziller, Ervin Hruby, Barbara Rigó, Gábor Szabó, Z. Papp

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a grave, life threatening form of pre-eclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Objective of the study: To assess the rate of maternal complications in HELLP syndrome. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. The authors summed up about their experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the course of the disease, postpartum maternal complications. Results: The frequency of HELLP syndrome in live births was found to be 0.37%. In 96% of the patients the pregnancy was terminated via Caesarean section. Pulmonary oedema was the most common cardiopulmonary complication (11%) and developed in Mississippi Group I in the majority of the cases (21%). Transfusions had to be given quite frequently; 62% of the patients in the study were transfused using erythrocyte preparations. In persistent or progressive cases in the postpartum period, the elimination (uterine curettage and lavage) of factors responsible for the persistence of the disease (toxic and vasoactive agents in the endometrium) resulted in the recovery of one third of the patients. Maternal thromboembolic complications developed in 11% of the patients, each of them was affected in Mississippi Group I, with the lowest platelet count. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. It is recommended to try and lift foci applying uterine curettage and lavage as the first step, if the mothers' condition persists or progresses after delivery. Its development is accompanied by a significant increase in maternal and fetal morbidity and mortality alike, therefore it is essential for the obstetricians to be familiar with the disease.

Original languageHungarian
Pages (from-to)1377-1386
Number of pages10
JournalOrvosi Hetilap
Volume147
Issue number29
Publication statusPublished - Jul 23 2006

Fingerprint

HELLP Syndrome
Mothers
Pregnancy
Mississippi
Curettage
Therapeutic Irrigation
Hemolysis
Platelet Count
Postpartum Period
Fetal Mortality
Hospital Obstetrics and Gynecology Department
Poisons
Liver
Live Birth
Pulmonary Edema
Enzymes
Endometrium
Pre-Eclampsia
Gynecology
Cesarean Section

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anyai szövodmények elofordulása 107 HELLP-szindrómával szövodött terhesség kapcsán. / Hupuczi, P.; Sziller, I.; Hruby, Ervin; Rigó, Barbara; Szabó, Gábor; Papp, Z.

In: Orvosi Hetilap, Vol. 147, No. 29, 23.07.2006, p. 1377-1386.

Research output: Contribution to journalArticle

Hupuczi, P. ; Sziller, I. ; Hruby, Ervin ; Rigó, Barbara ; Szabó, Gábor ; Papp, Z. / Anyai szövodmények elofordulása 107 HELLP-szindrómával szövodött terhesség kapcsán. In: Orvosi Hetilap. 2006 ; Vol. 147, No. 29. pp. 1377-1386.
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abstract = "Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a grave, life threatening form of pre-eclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Objective of the study: To assess the rate of maternal complications in HELLP syndrome. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. The authors summed up about their experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the course of the disease, postpartum maternal complications. Results: The frequency of HELLP syndrome in live births was found to be 0.37{\%}. In 96{\%} of the patients the pregnancy was terminated via Caesarean section. Pulmonary oedema was the most common cardiopulmonary complication (11{\%}) and developed in Mississippi Group I in the majority of the cases (21{\%}). Transfusions had to be given quite frequently; 62{\%} of the patients in the study were transfused using erythrocyte preparations. In persistent or progressive cases in the postpartum period, the elimination (uterine curettage and lavage) of factors responsible for the persistence of the disease (toxic and vasoactive agents in the endometrium) resulted in the recovery of one third of the patients. Maternal thromboembolic complications developed in 11{\%} of the patients, each of them was affected in Mississippi Group I, with the lowest platelet count. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. It is recommended to try and lift foci applying uterine curettage and lavage as the first step, if the mothers' condition persists or progresses after delivery. Its development is accompanied by a significant increase in maternal and fetal morbidity and mortality alike, therefore it is essential for the obstetricians to be familiar with the disease.",
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AU - Sziller, I.

AU - Hruby, Ervin

AU - Rigó, Barbara

AU - Szabó, Gábor

AU - Papp, Z.

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N2 - Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a grave, life threatening form of pre-eclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Objective of the study: To assess the rate of maternal complications in HELLP syndrome. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. The authors summed up about their experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the course of the disease, postpartum maternal complications. Results: The frequency of HELLP syndrome in live births was found to be 0.37%. In 96% of the patients the pregnancy was terminated via Caesarean section. Pulmonary oedema was the most common cardiopulmonary complication (11%) and developed in Mississippi Group I in the majority of the cases (21%). Transfusions had to be given quite frequently; 62% of the patients in the study were transfused using erythrocyte preparations. In persistent or progressive cases in the postpartum period, the elimination (uterine curettage and lavage) of factors responsible for the persistence of the disease (toxic and vasoactive agents in the endometrium) resulted in the recovery of one third of the patients. Maternal thromboembolic complications developed in 11% of the patients, each of them was affected in Mississippi Group I, with the lowest platelet count. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. It is recommended to try and lift foci applying uterine curettage and lavage as the first step, if the mothers' condition persists or progresses after delivery. Its development is accompanied by a significant increase in maternal and fetal morbidity and mortality alike, therefore it is essential for the obstetricians to be familiar with the disease.

AB - Introduction: HELLP syndrome (Haemolysis, Elevated Liver enzymes, Low platelet count) is a grave, life threatening form of pre-eclampsia, which was named by Weinstein in 1982, on the basis of characteristic changes in laboratory findings (haemolysis, elevated level of liver enzymes and thrombocytopenia). Objective of the study: To assess the rate of maternal complications in HELLP syndrome. Material and Methods: In the past ten years, 107 patients were treated for HELLP syndrome at the Intensive Care Unit (ICU) of the 1st Department of Obstetrics and Gynaecology, Semmelweis University. The authors summed up about their experience with the treatment of patients, with special regard to the typical symptoms of HELLP syndrome, the course of the disease, postpartum maternal complications. Results: The frequency of HELLP syndrome in live births was found to be 0.37%. In 96% of the patients the pregnancy was terminated via Caesarean section. Pulmonary oedema was the most common cardiopulmonary complication (11%) and developed in Mississippi Group I in the majority of the cases (21%). Transfusions had to be given quite frequently; 62% of the patients in the study were transfused using erythrocyte preparations. In persistent or progressive cases in the postpartum period, the elimination (uterine curettage and lavage) of factors responsible for the persistence of the disease (toxic and vasoactive agents in the endometrium) resulted in the recovery of one third of the patients. Maternal thromboembolic complications developed in 11% of the patients, each of them was affected in Mississippi Group I, with the lowest platelet count. Conclusions: The immediate termination of a pregnancy in which HELLP syndrome emerges may save the patient's life. It is recommended to try and lift foci applying uterine curettage and lavage as the first step, if the mothers' condition persists or progresses after delivery. Its development is accompanied by a significant increase in maternal and fetal morbidity and mortality alike, therefore it is essential for the obstetricians to be familiar with the disease.

KW - Diagnosis

KW - Frequency

KW - HELLP syndrome

KW - Maternal complications

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