Az RNS-vírusok kvázispecies jellege és önszabályozó mechanizmusa; példák ezek gyakorlati jelentöségére

Translated title of the contribution: The quasispecies nature and autoregulation of the replication of RNA viruses; practical examples

Kiss István, Bálint Ádám, Belák Sándor

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The extensive research on infectious diseases has lead to significant achievements in the last decades and at the same time, it presented new challenges. This paper summarizes the findings of the related literature, giving examples of veterinary concerns. The recognition of the existence of RNA viruses as a swarm of slightly different mutant variants, the so-called quasispecies, has begun shaping our understanding of the patomechanism of viral diseases and to reveal its complexity in deeper details. The survival and evolution of the viral quasispecies proposed to rely on the fidelity and processivity of the virus RNA dependent RNA polymerase enzyme, which are significantly and dynamically affected by other proteins of the virus, striving to reach equilibrium by a mechanism called replicative homeostasis. The comprehension of this autoregulation process helps to understand better phenomena like revertation of live vaccine viruses, change in tissue tropism, exacerbation of certain disease conditions, etc. For this purpose, it is very important to subject some selected samples/isolates of a given outbreak for deeper sequence analysis, i.e. to have at least the full-length consensus sequence of a given pathogen. The further analysis of the composition of the quasispecies could certainly provide more data, even of predictive value for epidemiological concerns, i.e., indicating the frequency of between animal virus transmission and the duration of infection.

Translated title of the contributionThe quasispecies nature and autoregulation of the replication of RNA viruses; practical examples
Original languageHungarian
Pages (from-to)425-438
Number of pages14
JournalMagyar Allatorvosok Lapja
Volume132
Issue number7
Publication statusPublished - Jul 1 2010

ASJC Scopus subject areas

  • veterinary(all)

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