The putative role of measles virus in the pathogenesis of otosclerosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The main goal of this report is to review our current knowledge about the etiopathogenesis of otosclerotic bone remodeling disorder focusing on measles virus infection. Otosclerosis is a disease of pathologically increased bone turnover of the human otic capsule; however, the etiopathogenesis remained unclear. Persisting measles virus infection, genetic predisposition, disturbed bone metabolism, inflammatory processes, autoimmunity, and hormonal and environmental factors also may play contributing roles in the pathogenesis of otosclerosis. In the future, prospective studies based on comprehensive histopathologic, molecular biologic, and genetic analysis are necessary to get further information about the background of disease in order to clarify the role of measles in the etiopathogenesis and to find the most promising treatment option.

Original languageEnglish
Title of host publicationSurgery of Stapes Fixations
PublisherSpringer International Publishing
Pages7-25
Number of pages19
ISBN (Electronic)9783319285764
ISBN (Print)9783319285740
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Etiopathogenesis
  • Genetics
  • Inflammation
  • Measles virus
  • Otosclerosis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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