The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition

Balázs Gulyás, S. Kéri, Brandon T. O'Sullivan, Jean Decety, Per E. Roland

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (γ-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by γ-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.

Original languageEnglish
Pages (from-to)595-600
Number of pages6
JournalNeurochemistry International
Volume44
Issue number8
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Norisoprenoids
Pheromones
Cognition
Human Pheromones
Cerebrovascular Circulation
Butanols
Glycols
Regional Blood Flow
Brain
Temporal Lobe
Prefrontal Cortex
Positron-Emission Tomography
Odorants

Keywords

  • Human pheromones
  • Olfaction
  • PET
  • Prefrontal cortex
  • Social cognition
  • Superior temporal cortex

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition. / Gulyás, Balázs; Kéri, S.; O'Sullivan, Brandon T.; Decety, Jean; Roland, Per E.

In: Neurochemistry International, Vol. 44, No. 8, 06.2004, p. 595-600.

Research output: Contribution to journalArticle

Gulyás, Balázs ; Kéri, S. ; O'Sullivan, Brandon T. ; Decety, Jean ; Roland, Per E. / The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition. In: Neurochemistry International. 2004 ; Vol. 44, No. 8. pp. 595-600.
@article{3e4b44c2ea424815b859d4d9566d85ed,
title = "The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition",
abstract = "Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (γ-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by γ-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.",
keywords = "Human pheromones, Olfaction, PET, Prefrontal cortex, Social cognition, Superior temporal cortex",
author = "Bal{\'a}zs Guly{\'a}s and S. K{\'e}ri and O'Sullivan, {Brandon T.} and Jean Decety and Roland, {Per E.}",
year = "2004",
month = "6",
doi = "10.1016/j.neuint.2003.10.003",
language = "English",
volume = "44",
pages = "595--600",
journal = "Neurochemistry International",
issn = "0197-0186",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition

AU - Gulyás, Balázs

AU - Kéri, S.

AU - O'Sullivan, Brandon T.

AU - Decety, Jean

AU - Roland, Per E.

PY - 2004/6

Y1 - 2004/6

N2 - Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (γ-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by γ-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.

AB - Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (γ-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by γ-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.

KW - Human pheromones

KW - Olfaction

KW - PET

KW - Prefrontal cortex

KW - Social cognition

KW - Superior temporal cortex

UR - http://www.scopus.com/inward/record.url?scp=1542358095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542358095&partnerID=8YFLogxK

U2 - 10.1016/j.neuint.2003.10.003

DO - 10.1016/j.neuint.2003.10.003

M3 - Article

C2 - 15016474

AN - SCOPUS:1542358095

VL - 44

SP - 595

EP - 600

JO - Neurochemistry International

JF - Neurochemistry International

SN - 0197-0186

IS - 8

ER -