The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues

P. Bork, N. P. Brown, H. Hegyi, J. Schultz

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

A thorough sequence analysis of the various members of the eukaryotic protein serine/threonine phosphatase 2C (PP2C) family revealed the conservation of 11 motifs. These motifs could be identified in numerous other sequences, including fungal adenylate cyclases that are predicted to contain a functionally active PP2C domain, and a family of prokaryotic serine/threonine phosphatases including SpoIIE. Phylogenetic analysis of all the proteins indicates a widespread sequence family for which a considerable number of isoenzymes can be inferred.

Original languageEnglish
Pages (from-to)1421-1425
Number of pages5
JournalProtein Science
Volume5
Issue number7
Publication statusPublished - 1996

Fingerprint

Phosphoprotein Phosphatases
Adenylyl Cyclases
Isoenzymes
Sequence Analysis
Conservation
Proteins
Protein Phosphatase 2C

Keywords

  • alignment
  • bacterial serine/threonine phosphatases
  • homology search
  • PP2C
  • SpoIIE

ASJC Scopus subject areas

  • Biochemistry

Cite this

The protein phosphatase 2C (PP2C) superfamily : Detection of bacterial homologues. / Bork, P.; Brown, N. P.; Hegyi, H.; Schultz, J.

In: Protein Science, Vol. 5, No. 7, 1996, p. 1421-1425.

Research output: Contribution to journalArticle

Bork, P, Brown, NP, Hegyi, H & Schultz, J 1996, 'The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues', Protein Science, vol. 5, no. 7, pp. 1421-1425.
Bork, P. ; Brown, N. P. ; Hegyi, H. ; Schultz, J. / The protein phosphatase 2C (PP2C) superfamily : Detection of bacterial homologues. In: Protein Science. 1996 ; Vol. 5, No. 7. pp. 1421-1425.
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