The protective effect of N-acetyl-aspartyl-glutamate (NAAGA) against nasal obstruction provoked by antigen in allergic rhinitis

P. Magyar, Z. Gyori, Z. Mark, I. Hutas

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Specific nasal challenge test (NCT) with pollen extracts was performed before and after a single dose pretreatment with N-acetyl-aspartyl-glutamate (NAAGA: Rhinaaxia®) nasal spray in 11 grass- and ragweed-pollen-sensitive patients wlth allergic rhinitis in symptom-free condition to test the protective effect of this drug on allergen-induced nasal obstruction and symptoms. In 7 of 11 patients, a third NCT was performed in the same way as the second one, except that placebo spray was used for pretreatment instead of NAAGA nasal spray. Nasal airways resistance (R(nas)) measurements were performed before pretreatment and 15 min after NCT. Pretreatment with NAAGA 1 h before NCT significantly (P <0.001) attenuated antigen-induced nasal obstruction. The mean protection was 64%. The protective effect against nasal symptoms was likewise significant (P <0.001), but the mean protection was found to be essentially lower (39%) than for R(nas). Pretreatment with placebo nasal spray showed only a 13% (P > 0.1) protection for R(nas), while it did not decrease allergen-induced nasal symptoms. The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction.

Original languageEnglish
Pages (from-to)631-633
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume48
Issue number8
Publication statusPublished - 1993

Fingerprint

Nasal Obstruction
Nose
Antigens
Nasal Sprays
Allergens
Protective Agents
Airway Resistance
Pollen
Poaceae
N-acetyl-1-aspartylglutamic acid
Allergic Rhinitis
Placebos

Keywords

  • grass pollen
  • N-acetyl-aspartyl-glutamate
  • nasal challenge
  • nasal obstruction
  • ragweed pollen

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "The protective effect of N-acetyl-aspartyl-glutamate (NAAGA) against nasal obstruction provoked by antigen in allergic rhinitis",
abstract = "Specific nasal challenge test (NCT) with pollen extracts was performed before and after a single dose pretreatment with N-acetyl-aspartyl-glutamate (NAAGA: Rhinaaxia{\circledR}) nasal spray in 11 grass- and ragweed-pollen-sensitive patients wlth allergic rhinitis in symptom-free condition to test the protective effect of this drug on allergen-induced nasal obstruction and symptoms. In 7 of 11 patients, a third NCT was performed in the same way as the second one, except that placebo spray was used for pretreatment instead of NAAGA nasal spray. Nasal airways resistance (R(nas)) measurements were performed before pretreatment and 15 min after NCT. Pretreatment with NAAGA 1 h before NCT significantly (P <0.001) attenuated antigen-induced nasal obstruction. The mean protection was 64{\%}. The protective effect against nasal symptoms was likewise significant (P <0.001), but the mean protection was found to be essentially lower (39{\%}) than for R(nas). Pretreatment with placebo nasal spray showed only a 13{\%} (P > 0.1) protection for R(nas), while it did not decrease allergen-induced nasal symptoms. The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction.",
keywords = "grass pollen, N-acetyl-aspartyl-glutamate, nasal challenge, nasal obstruction, ragweed pollen",
author = "P. Magyar and Z. Gyori and Z. Mark and I. Hutas",
year = "1993",
language = "English",
volume = "48",
pages = "631--633",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
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T1 - The protective effect of N-acetyl-aspartyl-glutamate (NAAGA) against nasal obstruction provoked by antigen in allergic rhinitis

AU - Magyar, P.

AU - Gyori, Z.

AU - Mark, Z.

AU - Hutas, I.

PY - 1993

Y1 - 1993

N2 - Specific nasal challenge test (NCT) with pollen extracts was performed before and after a single dose pretreatment with N-acetyl-aspartyl-glutamate (NAAGA: Rhinaaxia®) nasal spray in 11 grass- and ragweed-pollen-sensitive patients wlth allergic rhinitis in symptom-free condition to test the protective effect of this drug on allergen-induced nasal obstruction and symptoms. In 7 of 11 patients, a third NCT was performed in the same way as the second one, except that placebo spray was used for pretreatment instead of NAAGA nasal spray. Nasal airways resistance (R(nas)) measurements were performed before pretreatment and 15 min after NCT. Pretreatment with NAAGA 1 h before NCT significantly (P <0.001) attenuated antigen-induced nasal obstruction. The mean protection was 64%. The protective effect against nasal symptoms was likewise significant (P <0.001), but the mean protection was found to be essentially lower (39%) than for R(nas). Pretreatment with placebo nasal spray showed only a 13% (P > 0.1) protection for R(nas), while it did not decrease allergen-induced nasal symptoms. The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction.

AB - Specific nasal challenge test (NCT) with pollen extracts was performed before and after a single dose pretreatment with N-acetyl-aspartyl-glutamate (NAAGA: Rhinaaxia®) nasal spray in 11 grass- and ragweed-pollen-sensitive patients wlth allergic rhinitis in symptom-free condition to test the protective effect of this drug on allergen-induced nasal obstruction and symptoms. In 7 of 11 patients, a third NCT was performed in the same way as the second one, except that placebo spray was used for pretreatment instead of NAAGA nasal spray. Nasal airways resistance (R(nas)) measurements were performed before pretreatment and 15 min after NCT. Pretreatment with NAAGA 1 h before NCT significantly (P <0.001) attenuated antigen-induced nasal obstruction. The mean protection was 64%. The protective effect against nasal symptoms was likewise significant (P <0.001), but the mean protection was found to be essentially lower (39%) than for R(nas). Pretreatment with placebo nasal spray showed only a 13% (P > 0.1) protection for R(nas), while it did not decrease allergen-induced nasal symptoms. The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction.

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