LEBERPROTEKTIVE WIRKUNG DER VORBEHANDLUNG MIT STRAHLENDETOXIFIZIERTEM ENDOTOXIN (TOLERIN®) BEIM AKUTEN MYOKARDINFARKT DES HUNDES

Translated title of the contribution: The protective effect for the liver by pretreatment with radiologically detoxicated endotoxin (Tolerin®) in the acute myocardial infarction of dog

A. Balogh, I. Furka, P. Sótónyi, L. Dalmy, L. Bertók

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damage in the liver was shown electron microscopically 90 and 120 minutes after the beginning of the experiment. Destruction or disturbance in the permeability of the liver cells was not, or slightly developed by pretreatment with radiologically detoxicated endotoxin. In this case no aggravation of the liver function was evident parallel to the morphological changes and the ability of the liver to detoxicate endotoxin was preserved. The experiment shows that the protective effect of Tolerin which prevented the ischemic liver cell damage is not the endotoxin tolerance. The stabilizing effect of the lysosomal membrane by Tolerin is the likely cause.

Original languageGerman
Pages (from-to)156-164
Number of pages9
JournalZeitschrift fur Experimentelle Chirurgie
Volume14
Issue number3
Publication statusPublished - 1981

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Endotoxins
Myocardial Infarction
Dogs
Liver
Ligation
Permeability
Coronary Vessels
tolerin
Electrons
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "LEBERPROTEKTIVE WIRKUNG DER VORBEHANDLUNG MIT STRAHLENDETOXIFIZIERTEM ENDOTOXIN (TOLERIN{\circledR}) BEIM AKUTEN MYOKARDINFARKT DES HUNDES",
abstract = "An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damage in the liver was shown electron microscopically 90 and 120 minutes after the beginning of the experiment. Destruction or disturbance in the permeability of the liver cells was not, or slightly developed by pretreatment with radiologically detoxicated endotoxin. In this case no aggravation of the liver function was evident parallel to the morphological changes and the ability of the liver to detoxicate endotoxin was preserved. The experiment shows that the protective effect of Tolerin which prevented the ischemic liver cell damage is not the endotoxin tolerance. The stabilizing effect of the lysosomal membrane by Tolerin is the likely cause.",
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AU - Balogh, A.

AU - Furka, I.

AU - Sótónyi, P.

AU - Dalmy, L.

AU - Bertók, L.

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AB - An acute myocardial infarction was produced in experiments in dogs by ligature of the ramus anterior of the left coronary artery. Cell damage in the liver was shown electron microscopically 90 and 120 minutes after the beginning of the experiment. Destruction or disturbance in the permeability of the liver cells was not, or slightly developed by pretreatment with radiologically detoxicated endotoxin. In this case no aggravation of the liver function was evident parallel to the morphological changes and the ability of the liver to detoxicate endotoxin was preserved. The experiment shows that the protective effect of Tolerin which prevented the ischemic liver cell damage is not the endotoxin tolerance. The stabilizing effect of the lysosomal membrane by Tolerin is the likely cause.

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