The prognostic value of dopamine receptor occupancy by [123I]IBZM-SPECT in schizophrenic patients treated with quetiapine

László Pávics, György Szekeres, Edit Amrus, Szabolcs Kéri, Zoltán Kovács, Miklós Árgyelán, Balázs Kanyó, László Csernay, Zoltán Janka

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4 Citations (Scopus)

Abstract

Background: In the present study D2 receptor occupancy was investigated in quetiapine treated schizophrenic patients for the detection of a relationship between the scintigraphic pattern and clinical signs and symptoms. Material and methods: In 10 schizophrenic patients [123I]IBZM-SPECTs were performed during the introduction of quetiapine therapy (600-800 mg/day) and during a lower maintenance dose (200-400 mg/day). The patients' clinical follow-up was continued for 1 year. For the evaluation of SPECT images, visual interpretation was performed and striatum/occipital lobe (S/O) activity ratio was calculated. Results: The initial striatum/occipital ratio was significantly higher in patients with relapse compared to the others (1.86 ± ± 0.17, 1.53 ± 0.15, p < 0.01). The decreasing striatum/occipital ratio (increasing D2 receptor occupancy) on the 2nd SPECT was a predictive factor for the relapse. Conclusions: D2 receptor occupancy and its changes during quetiapine therapy were related to the prognosis of the treatment efficacy.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalNuclear Medicine Review
Volume7
Issue number2
Publication statusPublished - Dec 1 2004

Keywords

  • Clinical follow-up
  • IBZM-SPECT
  • Quetiapine
  • Schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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