The prognostic value of cadherin switch in bladder cancer

Tobias Jäger, Markus Becker, Andreas Eisenhardt, Derya Tilki, Martin Tötsch, Kurt W. Schmid, I. Romics, Herbert Rübben, Süleyman Ergün, Tibor Szarvas

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Loss of E-cadherin expression and gain of N-cadherin expression ('cadherin switch') is shown to be characteristic in epithelial to mesenchymal transition (EMT), a mechanism associated with cancer progression. Furthermore, the prognostic role of P-cadherin in different cancers is controversial. The aim of this study was to evaluate the prognostic significance of 'cadherin switch' on the gene expression level in bladder cancer. Frozen tissue samples of 181 bladder cancer patients and 7 control individuals were analyzed by quantitative real-time PCR. Kaplan-Meier logrank test and Cox univariate and multivariate analysis were performed to assess the prognostic relevance of gene expression of E-, N- and P-cadherin. Cox univariate analysis revealed that the decrease of E-cadherin and the gain of Ncadherin gene expression are risk factors for cancer-related death (P=0.087, P=0.005, respectively). Fourteen percent (13/92) of muscle-invasive bladder cancers were N-cadherinnegative. These patients had a significantly poorer prognosis than those with N-cadherin-positive muscle-invasive tumors (P=0.024). P-cadherin gene expression proved to be a significant independent prognostic factor for both cancerspecific and recurrence-free survival (P=0.011, P=0.036). The characteristic 'cadherin switch' between low- and high-stage tumors that we observed and the prognostic significance of E-, N- and P-cadherin suggests the importance of these markers in bladder cancer progression. The poor patient prognosis in N-cadherin-negative muscle-invasive tumors indicates an alternative, N-cadherin-independent way in bladder cancer progression.

Original languageEnglish
Pages (from-to)1125-1132
Number of pages8
JournalOncology Reports
Volume23
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Cadherins
Urinary Bladder Neoplasms
Gene Expression
Neoplasms
Muscles
Switch Genes
Epithelial-Mesenchymal Transition
Kaplan-Meier Estimate
Real-Time Polymerase Chain Reaction
Multivariate Analysis

Keywords

  • Bladder cancer
  • Cadherin switch
  • E-cadherin
  • N-cadherin
  • P-cadherin
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Jäger, T., Becker, M., Eisenhardt, A., Tilki, D., Tötsch, M., Schmid, K. W., ... Szarvas, T. (2010). The prognostic value of cadherin switch in bladder cancer. Oncology Reports, 23(4), 1125-1132. https://doi.org/10.3892/or-00000741

The prognostic value of cadherin switch in bladder cancer. / Jäger, Tobias; Becker, Markus; Eisenhardt, Andreas; Tilki, Derya; Tötsch, Martin; Schmid, Kurt W.; Romics, I.; Rübben, Herbert; Ergün, Süleyman; Szarvas, Tibor.

In: Oncology Reports, Vol. 23, No. 4, 04.2010, p. 1125-1132.

Research output: Contribution to journalArticle

Jäger, T, Becker, M, Eisenhardt, A, Tilki, D, Tötsch, M, Schmid, KW, Romics, I, Rübben, H, Ergün, S & Szarvas, T 2010, 'The prognostic value of cadherin switch in bladder cancer', Oncology Reports, vol. 23, no. 4, pp. 1125-1132. https://doi.org/10.3892/or-00000741
Jäger T, Becker M, Eisenhardt A, Tilki D, Tötsch M, Schmid KW et al. The prognostic value of cadherin switch in bladder cancer. Oncology Reports. 2010 Apr;23(4):1125-1132. https://doi.org/10.3892/or-00000741
Jäger, Tobias ; Becker, Markus ; Eisenhardt, Andreas ; Tilki, Derya ; Tötsch, Martin ; Schmid, Kurt W. ; Romics, I. ; Rübben, Herbert ; Ergün, Süleyman ; Szarvas, Tibor. / The prognostic value of cadherin switch in bladder cancer. In: Oncology Reports. 2010 ; Vol. 23, No. 4. pp. 1125-1132.
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