The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone

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We studied DNA ploidy by smear cytophotometry and proliferation activity by Ki-67 MIB immunohistochemistry in 69 primary and recurrent giant cell tumors (GCT) from 50 randomly selected patients. The obtained results were evaluated with comparisons made to the available clinical data. From the 46 primary tumors 63% showed diploidy and 37% aneuploidy. A significantly (P = 0.026) higher recurrence rate (64%) was observed in aneuploid than in diploid tumors (31%). In the course of the recurrences, both the ratio of aneuploid tumors as well as the proliferation index of the tumors increased, though the degree of the latter was non-significant. Aneuploidy did not mean an unambiguous tendency towards malignant transformation; however, a close follow-up of recurrent aneuploid tumors, and wide excision of the recurrence instead of intralesional curettage are the recommended procedures. The DNA cytophotometry and proliferation index of GCTs - as compared to other histologic examinations - are of prognostic value in the evaluation of the recurrence potential of the GCTs.

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalInternational Orthopaedics
Issue number6
Publication statusPublished - Dec 1 1999


ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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