The process of learning in rats undergoing prolonged treatment with psychotropic agents

I. Dési, P. Kertai, I. Farkas, Zs Muskó, P. Hajós

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of amphetamine and chlorpromazine on the process of learning and the change in performance of acquired skills in rats was studied. Maze tests were camed out for 23 days and conditioned reflex tests for 37 days. Animals received 0.5 mg/kg/day of amphetamine or 0.5 mg/kg/day of chlorpromazine added to the drinking water. Further groups received daily intraperitoneal injections of 0.25 mg/kg of amphetamine or 4 mg/kg of chlorpromazine. The learning index deteriorated initially by oral administration of amphetamine, but subsequently improved, whereas intraperitoneal treatment caused a slight deterioration. Both agents interfered with previously acquired conditioned responses. The frequency of pseudopositive responses was considerably higher following administration of amphetamine, but was unalterated by chlorpromazine.

Original languageEnglish
Pages (from-to)144-153
Number of pages10
JournalPsychopharmacology
Volume18
Issue number2
DOIs
Publication statusPublished - Jun 1970

Fingerprint

Amphetamine
Chlorpromazine
Learning
Therapeutics
Classical Conditioning
Intraperitoneal Injections
Drinking Water
Oral Administration

Keywords

  • Amphetamine
  • Behaviour
  • Chlorpromazine
  • Conditioned Reflexes
  • Maze-Learning

ASJC Scopus subject areas

  • Pharmacology

Cite this

The process of learning in rats undergoing prolonged treatment with psychotropic agents. / Dési, I.; Kertai, P.; Farkas, I.; Muskó, Zs; Hajós, P.

In: Psychopharmacology, Vol. 18, No. 2, 06.1970, p. 144-153.

Research output: Contribution to journalArticle

Dési, I. ; Kertai, P. ; Farkas, I. ; Muskó, Zs ; Hajós, P. / The process of learning in rats undergoing prolonged treatment with psychotropic agents. In: Psychopharmacology. 1970 ; Vol. 18, No. 2. pp. 144-153.
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