The prevalence of prostate carcinoma and its precursor in Hungary: An autopsy study

G. Soós, Ioannis Tsakiris, J. Szántó, Csaba Turzo, P. Gabriel Haas, B. Dezső

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.

Original languageEnglish
Pages (from-to)739-744
Number of pages6
JournalEuropean Urology
Volume48
Issue number5
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Hungary
Prostate
Autopsy
Adenocarcinoma
Carcinoma
Neoplasms
Urologic Diseases
Hematoxylin
Eosine Yellowish-(YS)
Tumor Burden
Paraffin
Formaldehyde
Prostatic Neoplasms
Age Groups
Incidence
Population

Keywords

  • Autopsy
  • Central European Caucasian males
  • Epidemiology
  • HGPIN
  • Histology
  • Hungary
  • Incidental prostate carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

The prevalence of prostate carcinoma and its precursor in Hungary : An autopsy study. / Soós, G.; Tsakiris, Ioannis; Szántó, J.; Turzo, Csaba; Haas, P. Gabriel; Dezső, B.

In: European Urology, Vol. 48, No. 5, 11.2005, p. 739-744.

Research output: Contribution to journalArticle

Soós, G. ; Tsakiris, Ioannis ; Szántó, J. ; Turzo, Csaba ; Haas, P. Gabriel ; Dezső, B. / The prevalence of prostate carcinoma and its precursor in Hungary : An autopsy study. In: European Urology. 2005 ; Vol. 48, No. 5. pp. 739-744.
@article{f3727d4f9a3c437cad763d049f3f3710,
title = "The prevalence of prostate carcinoma and its precursor in Hungary: An autopsy study",
abstract = "Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8{\%} prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6{\%} and 60{\%} of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.",
keywords = "Autopsy, Central European Caucasian males, Epidemiology, HGPIN, Histology, Hungary, Incidental prostate carcinoma",
author = "G. So{\'o}s and Ioannis Tsakiris and J. Sz{\'a}nt{\'o} and Csaba Turzo and Haas, {P. Gabriel} and B. Dezső",
year = "2005",
month = "11",
doi = "10.1016/j.eururo.2005.08.010",
language = "English",
volume = "48",
pages = "739--744",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - The prevalence of prostate carcinoma and its precursor in Hungary

T2 - An autopsy study

AU - Soós, G.

AU - Tsakiris, Ioannis

AU - Szántó, J.

AU - Turzo, Csaba

AU - Haas, P. Gabriel

AU - Dezső, B.

PY - 2005/11

Y1 - 2005/11

N2 - Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.

AB - Objectives: The prevalence of incidental prostatic adenocarcinoma (PCa) and its precursor, high grade intraepithelial neoplasia (HGPIN) in an autopsy series from Hungarians (Central European Caucasians) was assessed and compared to similar data from the United States and European countries. Methods: Autopsy cases (n = 139; 18-95 years) with no history of urological disease were histologically examined for prostate cancer and HGPIN. After en block removal, the prostate glands were fixed in formalin, sectioned at 3-5 mm intervals and embedded in paraffin. Whole-mount serial sections were stained with Hematoxylin-eosin and examined for the presence of PCa and HGPIN. The frequency of PCa and HGPIN was compared to autopsy data obtained from other geographical areas. Results: We found a 38.8% prevalence of incidental PCa with increasing age-related incidence. Both PCa and HGPIN are first detected in the 3rd decade and show a steady increase with age with respect to number of foci, tumor grade and volume. In the age group 81-95, 86.6% and 60% of men had PCa and HGPIN, respectively. Conclusions: Incidental PCa and HGPIN are very prevalent in Hungarian population, comparable with the high US and the Scandinavian epidemiological data for Caucasians.

KW - Autopsy

KW - Central European Caucasian males

KW - Epidemiology

KW - HGPIN

KW - Histology

KW - Hungary

KW - Incidental prostate carcinoma

UR - http://www.scopus.com/inward/record.url?scp=27144539204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27144539204&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2005.08.010

DO - 10.1016/j.eururo.2005.08.010

M3 - Article

C2 - 16203079

AN - SCOPUS:27144539204

VL - 48

SP - 739

EP - 744

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 5

ER -