Herpeszvírusok elofordulása humán periodontitis apicalis mintákban.

Translated title of the contribution: [The prevalance of herpesviruses in human apical periodontitis samples].

Katinka Hernádi, Anita Szalmás, Richard Mogyorósi, Levente Czompa, G. Veress, Eszter Csoma, I. Márton, József Kónya

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Apical periodontitis is primarily initiated by the endodonto-patogen bacteria spreading from the inflamed or necrotic pulp tissues to the periapical area. Nevertheless, findings within the past years have established a pathogenic role of human herpesviruses such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) in periapical inflammations. The authors analysed the prevalence, activity and disease association of EBV, HCMV and human herpesvirus 6 (HHV-6) in 40 apical periodontitis samples and 40 healthy pulp controls. Based on the viral DNA results, EBV (29/40) was the most frequent herpesvirus in apical periodontitis, followed by HHV-6 (8/40) and HCMV (4/40). According to the mRNA results approximately two-third of the EBV DNA-positive lesions had active EBV infections. However, the HHV-6 and the HCMV infections seemed to be of latent state. Our findings suggest that EBV and HHV-GB infections primarily occurred in large sized and symptomatic periapical lesions. The co-occurrence of large lesion size and active EBV infection was strongly associated (OR = 8.80) with the symptomatic manifestation of apical periodontitis.

Original languageHungarian
Pages (from-to)135-140
Number of pages6
JournalFogorvosi szemle
Volume105
Issue number4
Publication statusPublished - Dec 2012

Fingerprint

Periapical Periodontitis
Herpesviridae
Human Herpesvirus 4
Human Herpesvirus 6
Cytomegalovirus
Epstein-Barr Virus Infections
Periapical Tissue
Human Herpesvirus 8
Viral DNA
Cytomegalovirus Infections
Inflammation
Bacteria
Messenger RNA
DNA
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hernádi, K., Szalmás, A., Mogyorósi, R., Czompa, L., Veress, G., Csoma, E., ... Kónya, J. (2012). Herpeszvírusok elofordulása humán periodontitis apicalis mintákban. Fogorvosi szemle, 105(4), 135-140.

Herpeszvírusok elofordulása humán periodontitis apicalis mintákban. / Hernádi, Katinka; Szalmás, Anita; Mogyorósi, Richard; Czompa, Levente; Veress, G.; Csoma, Eszter; Márton, I.; Kónya, József.

In: Fogorvosi szemle, Vol. 105, No. 4, 12.2012, p. 135-140.

Research output: Contribution to journalArticle

Hernádi, K, Szalmás, A, Mogyorósi, R, Czompa, L, Veress, G, Csoma, E, Márton, I & Kónya, J 2012, 'Herpeszvírusok elofordulása humán periodontitis apicalis mintákban.', Fogorvosi szemle, vol. 105, no. 4, pp. 135-140.
Hernádi K, Szalmás A, Mogyorósi R, Czompa L, Veress G, Csoma E et al. Herpeszvírusok elofordulása humán periodontitis apicalis mintákban. Fogorvosi szemle. 2012 Dec;105(4):135-140.
Hernádi, Katinka ; Szalmás, Anita ; Mogyorósi, Richard ; Czompa, Levente ; Veress, G. ; Csoma, Eszter ; Márton, I. ; Kónya, József. / Herpeszvírusok elofordulása humán periodontitis apicalis mintákban. In: Fogorvosi szemle. 2012 ; Vol. 105, No. 4. pp. 135-140.
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