The presence of human papillomavirus 16 in neural structures and vascular endothelial cells

T. Füle, Miklós Máthé, Z. Suba, Z. Csapó, Tibor Szarvas, P. Tátrai, S. Paku, I. Kovalszky

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Human papillomavirus (HPV) is known as a strictly epitheliotropic pathogen. Our results raised the possibility that HPV 16 is present in neural cells and in the vascular endothelium. By in situ hybridization, we have detected HPV 16 E6 ORF sequence in small blood vessels and peripheral nerves adjacent to oral and cervical cancers. The same structures have clearly shown immunohistochemical reactivity for the E6 oncoprotein. These results were verified by PCR applied to E6 and L1 ORFs following microscopic laser dissection of the immunohistochemically positive nerves and vessels. These observations suggest that HPV 16 DNA and protein are present in neurons and endothelial cells in the vicinity of HPV-associated tumors. The HPV 16 genome presumably exists in a non-replicating form in the neurons and constitutively produces high levels of E6 and E7 proteins with an unknown neuropathological outcome.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalVirology
Volume348
Issue number2
DOIs
Publication statusPublished - May 10 2006

Fingerprint

Human papillomavirus 16
Endothelial Cells
Open Reading Frames
Neurons
Mouth Neoplasms
Oncogene Proteins
Vascular Endothelium
Peripheral Nerves
Uterine Cervical Neoplasms
In Situ Hybridization
Blood Vessels
Dissection
Proteins
Lasers
Genome
Polymerase Chain Reaction
DNA
Neoplasms

Keywords

  • Cervical cancer
  • Endothelium
  • HPV
  • Neuron
  • Oral cancer
  • Papillomavirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

The presence of human papillomavirus 16 in neural structures and vascular endothelial cells. / Füle, T.; Máthé, Miklós; Suba, Z.; Csapó, Z.; Szarvas, Tibor; Tátrai, P.; Paku, S.; Kovalszky, I.

In: Virology, Vol. 348, No. 2, 10.05.2006, p. 289-296.

Research output: Contribution to journalArticle

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AU - Szarvas, Tibor

AU - Tátrai, P.

AU - Paku, S.

AU - Kovalszky, I.

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