The preparation and anticancer activity of some phosphorus heterocycles

Harry R. Hudson, Gyorgy Keglevich

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20 Citations (Scopus)


Methods for the preparation of some phosphorus heterocycles are reviewed, together with a preliminary report of their activity in vitro against the NCI 60-cell line panel of human tumour cells. The most active compound, a dimer of 3-methyl-1-(2,4,6-triisopropylphenyl)phosphole oxide, showed GI50 values in the micromolar region against leukaemia cell lines RPMI-8226 and SR, non-small cell lung cancer (NCI-H460), colon cancer (COLO 205), and melanoma (SK-Mel-5 and UACC-62).

Original languageEnglish
Pages (from-to)2256-2261
Number of pages6
JournalPhosphorus, Sulfur and Silicon and the Related Elements
Issue number9
Publication statusPublished - Sep 1 2008



  • Anticancer
  • Dihydrophosphinine
  • NCI
  • Organophosphorus
  • Phosphanorbornene
  • Phosphole oxide
  • Phosphorus heterocycle
  • Tetrahydrophosphinine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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