The prandial insulin sensitivity-modifying effect of vagal stimulation in rats

Barna Peitl, Róbert Döbrönte, J. Németh, Géza Mezey, Péter Kovács, G. Paragh, Z. Szilvássy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The effect of left cervical vagal nerve stimulation was studied on insulin sensitivity to test the proposed permissive insulin-sensitizing role of hepatic vagal parasympathetic efferent pathways in fasted and fed anesthetized rats. In fed animals, electrical stimulation (square impulses: 25 V, 5 Hz, 0.5 milliseconds over 15 minutes) of the vagal nerve induced hyperglycemia and an increase in plasma insulin immunoreactivity. Atropine (1.0 mg/kg intravenously) induced insulin resistance estimated by rapid insulin sensitivity testing. This was amplified when the vagal nerve was stimulated. The insulin-resistant state developed by fasting was not modified by either treatment with atropine or electrical stimulation. We conclude that both parasympathetic cholinergic and noncholinergic vagal efferents modulate postprandial neurogenic insulin sensitivity adjustments.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume54
Issue number5
DOIs
Publication statusPublished - May 2005

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Meals
Insulin Resistance
Insulin
Atropine
Electric Stimulation
Vagus Nerve Stimulation
Efferent Pathways
Social Adjustment
Hyperglycemia
Cholinergic Agents
Fasting
Liver
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The prandial insulin sensitivity-modifying effect of vagal stimulation in rats. / Peitl, Barna; Döbrönte, Róbert; Németh, J.; Mezey, Géza; Kovács, Péter; Paragh, G.; Szilvássy, Z.

In: Metabolism: Clinical and Experimental, Vol. 54, No. 5, 05.2005, p. 579-583.

Research output: Contribution to journalArticle

Peitl, Barna ; Döbrönte, Róbert ; Németh, J. ; Mezey, Géza ; Kovács, Péter ; Paragh, G. ; Szilvássy, Z. / The prandial insulin sensitivity-modifying effect of vagal stimulation in rats. In: Metabolism: Clinical and Experimental. 2005 ; Vol. 54, No. 5. pp. 579-583.
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