The potential role of the osteoblast in the development of periprosthetic osteolysis: Review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth Factors

C. Vermes, Tibor T. Glant, Nadim J. Hallab, Elizabeth A. Fritz, Kenneth A. Roebuck, Joshua J. Jacobs

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Limited information is available on the responses of osteoblasts to wear debris, corrosion products, and cytokines and on the roles of altered osteoblast functions in the development of periprosthetic bone loss. Wear debris-challenged osteoblasts exhibit altered functions resulting in the loss of their capacity to produce bone.matrix and to replace the resorbed bone. Also, osteoblasts may secrete cytokines, which act in a paracrine fashion to recruit inflammatory cells into the periprosthetic space and to stimulate osteoclastic bone resorption. These effects may be mediated in part by ionic metal dissolution products. We review the mechanisms by which altered osteoblast functions, in response to particulate wear debris, corrosion products, and cytokines and growth factors, may contribute to the development and the progression of periprosthetic osteolysis.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalJournal of Arthroplasty
Volume16
Issue number8 SUPPL. 1
DOIs
Publication statusPublished - 2001

Fingerprint

Osteolysis
Corrosion
Osteoblasts
Intercellular Signaling Peptides and Proteins
Cytokines
Bone and Bones
Bone Development
Bone Resorption
Metals
In Vitro Techniques

Keywords

  • Collagen
  • Cytokine
  • Growth factor
  • Metal ion
  • Osteoblast
  • Particle wear debris

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

The potential role of the osteoblast in the development of periprosthetic osteolysis : Review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth Factors. / Vermes, C.; Glant, Tibor T.; Hallab, Nadim J.; Fritz, Elizabeth A.; Roebuck, Kenneth A.; Jacobs, Joshua J.

In: Journal of Arthroplasty, Vol. 16, No. 8 SUPPL. 1, 2001, p. 95-100.

Research output: Contribution to journalArticle

Vermes, C. ; Glant, Tibor T. ; Hallab, Nadim J. ; Fritz, Elizabeth A. ; Roebuck, Kenneth A. ; Jacobs, Joshua J. / The potential role of the osteoblast in the development of periprosthetic osteolysis : Review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth Factors. In: Journal of Arthroplasty. 2001 ; Vol. 16, No. 8 SUPPL. 1. pp. 95-100.
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