The potential of BioArena in the study of the formaldehydome

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

New results with BioArena as a complex separation and detection (evaluation) system support earlier observations that formaldehyde (HCHO) and its reaction products play a special and crucial role in the effects of antibiotic in general. It has been established that antibiotic-like compounds (e.g. trans-resveratrol, Cu(II) ions) have a duplicate inhibiting effect on pathogen cells as a result of the action of HCHO. HCHO as a key molecule of the formaldehydome participates in series of interactions which can be screened by means of different spectroscopic and chromatographic techniques; accumulation of HCHO and its reaction products in TLC spots is limited, however, so indirect detection is advantageous. In BioArena the planar stationary phase bed after TLC/HPTLC and, mainly, OPLC separation can be used for manifestation of deprivation of HCHO from antibiotic spots, for observation of the duplicate effect of substances with a direct effect, and for demonstration of cell proliferation promotion and retardation.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalJournal of Planar Chromatography - Modern TLC
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

Keywords

  • BioArena
  • Bioautography
  • Formaldehyde cycle
  • Formaldehydome
  • OPLC

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'The potential of BioArena in the study of the formaldehydome'. Together they form a unique fingerprint.

  • Cite this