The ratio of the plasma concentration of glycine + serine + glutamine + taurine to the concentration of leucine + isoleucine + valine + methionine in infants born after pregnancies complicated by toxaemia, placental infarction, partial obstruction of the umbilical cord and severe chronic maternal diseases has been studied by Whitehead method using paper chromatography. The following results were obtained: 1. The mean postnatal rise in the ratio after toxaemic pregnancies was found to be significantly greater than that observed previously in infants born to mothers with uncomplicated pregnancies; 2. while the mean ratio found between 16 and 24 hours after birth did not differ very much between toxaemic primiparae and multiparae, it was found to be significantly higher in boys than in girls; 3. pregnancies associated with placental infarction, partially obstructed umbilical circulation and severe, chronic maternal diseases were also associated with a profound postnatal increase in the palsma amino acid ratio; 4. the higher ratio observed in the different scries of examinations was due to a more pronounced opposite response in the plasma level of the two groups of amino acids than in infants born after normal pregnancies. It is suggested that pregnancies complicated by such conditions are often associated with a qualitatively and quantitatively deficient amino acid supply which may cause more marked postnatal changes in the plasma concentrations of the non-essential and essential group of amino acid than under normal conditions.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology