The possible role of isolated lymphoid follicles in colonic mucosal repair

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The continuous reformation and rapid repair of the colonic mucosa is essential for avoiding the aggregation of pernicious mutations induced by bacterial, toxic, or mitogenic factors. Gut-associated lymphoid tissue is supposed to play a central role in the organization of the repair mechanisms. In inflammatory conditions, the number, the diameter and the density of isolated lymphoid follicles (ILFs) are increasing. They are involved not just in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. The relation of ILFs to the components of mucosal renewal such as bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts or crypt formation has not been directly studied, and data about their putative organizer role are scattered in scientific literature. Whether they act as a regenerative pool containing stem cells in case of mucosal damage, or they are responsible only for the optimal cytokine milieu for the differentiation of immigrating stem cells is a question under debate. Our aim is to review the relation of ILFs to the different elements of colonic mucosal repair.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalPathology and Oncology Research
Volume16
Issue number1
DOIs
Publication statusPublished - Mar 2010

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Keywords

  • Bone marrow
  • Colon
  • Epithelial stem cell
  • Follicular dendritic cell
  • Isolated lymphoid follicle
  • Mesenchymal-epithelial transition
  • Mucosal repair
  • Myofibroblast

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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