The possible relationship between onco/suppressor gene expression and carcinogen exposure In Vivo: Evaluation of a potential biomarker in preventive and predictive medicine

István Ember, Zoltán Gyöngyi, István Kiss, Nowrasteh Ghodratollah, István Arany

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

An understanding of the molecular changes occuring during exposure to a carcinogen enhances the possibility of cancer prevention. Molecular genetic-biological screening methods offer the potential for early diagnosis of high-risk groups, and identification of specific signals, as a major step in primary prevention. Recent investigations have suggested that oncogene or oncosuppressor gene expression investigation at the RNA level is a proper and early molecular epidemiological biomarker of carcinogen exposure and a tool for risk assessment. This is one way by which the high-risk groups could be recognized. At the protein level, the investigation of gene expression is very useful in molecular diagnosis and in molecular pathology.

Original languageEnglish
Pages (from-to)2109-2116
Number of pages8
JournalAnticancer research
Volume22
Issue number4
Publication statusPublished - Aug 19 2002

Keywords

  • Carcinogenesis
  • Oncogenes
  • Preventive medicine
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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