171 patients with Graves' disease were HLA typed for A and B locus antigens. The frequency of HLA-A1 and B8 antigens have been observed to be significantly increased (P<0.0001). An extremely strong linkage disequilibrium for A1, B8 was found (P<0.001). Correlation has become established between the presence of the B8 antigens and ophthalmopathy (p<0.001), increased human thyroglobulin antibody titer (p<0.001) and lymphocyte transformation index (p<0.001). On this experimental basis, the B8 antigen seems to play such an important role in the course of the disease that it is useful for the clinicians to know the HLA antigens of the patients.
|Number of pages||2|
|Publication status||Published - Dec 1 1978|
ASJC Scopus subject areas