THE POLYMORPHIC HUMAN TLX‐B/CD46/MCP SYSTEM AND ITS IMPLICATIONS IN TRANSPLANTATION AND REPRODUCTION

G. Petränyi, A. Padányi, J. Szelényi, G. Sármay, Gyódi, V. Fülöp, M. Kassai, P. Illés, M. Réti, I. Szigetvári, P. Boros

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Abstract

TLX antigens have been found on most peripheral blood cells, trophoblasts, seminal vesicle cells and sperms. These antigens seem to be associated with the membrane co‐factor protein (MCP) and the CD46 antigen. Alloantibodies to TLX antigens with FctRII‐blocking features were obtained by transfusion of leucocytes or platelets. Preliminary population studies revealed that alloantibodies to TLX/CD46/MCP recognize four overlapping specificities. The terminology TLX‐B was introduced with specificities TLX‐BI, B2, B3, B4 and frequencies obtained in the population were: 38%, 46%, 42% and 26%, respectively. Family studies showed an independent segregation of the TLX and HLA alleles. At the cellular protein on trophoblast, the alloantibody detected a glycoprotein of 66‐67 kDa molecular mass, which may correspond to the a chain of the TLX/CD46/MCP isotypes. A direct association of the alloantibody with FctRII could be excluded thus its FctR blocking feature is probably based on an indirect functional effect. After transfusion and in pregnancy the induction of TLX alloantibody production depended on the mismatching in the TLX/CD46/MCP phenotypes. Probable associations were revealed in the case of recurrent habitual abortion between the lack of FCTR blocking antibody production and the matched TLX specificities of the couples. After transfusion, TLX alloantibody production with FCTR and MLR blocking function was induced only when the recipient was lacking the TLX specificities expressed on the donor cells. Suppression of MLR was found only when TLX specificity in sera corresponded to the TLX specificity of the effector cell. The immunopathological importance of these findings in transplantation and reproductive medicine has yet to be clarified.

Original languageEnglish
Pages (from-to)147-161
Number of pages15
JournalInternational Journal of Immunogenetics
Volume22
Issue number2
DOIs
Publication statusPublished - Apr 1995

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ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Petränyi, G., Padányi, A., Szelényi, J., Sármay, G., Gyódi, Fülöp, V., Kassai, M., Illés, P., Réti, M., Szigetvári, I., & Boros, P. (1995). THE POLYMORPHIC HUMAN TLX‐B/CD46/MCP SYSTEM AND ITS IMPLICATIONS IN TRANSPLANTATION AND REPRODUCTION. International Journal of Immunogenetics, 22(2), 147-161. https://doi.org/10.1111/j.1744-313X.1995.tb00225.x