The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells

Agoston Ember, Jeb S. Clark, Timea Varjas, Istvan Kiss, I. Ember, Radhakrishna Baliga, Istvan Arany

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Cancer therapies and cancer progression can increase oxidative stress that might account for renal toxicity in cancer patients. Flavin 7® (F7) is a natural polyphenol-containing dietary supplement with potential antioxidant activity. Therefore, it might help to attenuate renal toxicity of chemotherapeutics. Materials and Methods: Cultured mouse renal proximal tubule cells were subjected to H2O2-mediated oxidative stress. Potential antioxidant effects of F7 were assessed by measuring the production of reactive oxygen species (ROS), mitochondrial depolarization and injury (lactate dehydrogenase release as well as trypan blue exclusion) in cells that were pretreated with F7 prior to treatment with H2O2. Results: F7 pretreatment significantly attenuated H2O2-induced ROS production, mitochondrial depolarization and consequent injury in renal proximal tubule cells. Conclusion: F7 supplementation might be beneficial for cancer patients in order to prevent renal toxicity of anticancer drug- or cancer progression-related oxidative stress.

Original languageEnglish
Pages (from-to)975-978
Number of pages4
JournalIn Vivo
Volume23
Issue number6
Publication statusPublished - Nov 2009

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Proximal Kidney Tubule
Oxidative stress
Phytochemicals
Oxidative Stress
Toxicity
Depolarization
Neoplasms
Kidney
Reactive Oxygen Species
Dietary supplements
Antioxidants
Trypan Blue
Wounds and Injuries
Polyphenols
Dietary Supplements
Drug-Related Side Effects and Adverse Reactions
L-Lactate Dehydrogenase
4,6-dinitro-o-cresol
Therapeutics
Pharmaceutical Preparations

Keywords

  • Antioxidant
  • Bioflavonoid
  • Oxidative stress
  • Renal toxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Ember, A., Clark, J. S., Varjas, T., Kiss, I., Ember, I., Baliga, R., & Arany, I. (2009). The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells. In Vivo, 23(6), 975-978.

The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells. / Ember, Agoston; Clark, Jeb S.; Varjas, Timea; Kiss, Istvan; Ember, I.; Baliga, Radhakrishna; Arany, Istvan.

In: In Vivo, Vol. 23, No. 6, 11.2009, p. 975-978.

Research output: Contribution to journalArticle

Ember, A, Clark, JS, Varjas, T, Kiss, I, Ember, I, Baliga, R & Arany, I 2009, 'The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells', In Vivo, vol. 23, no. 6, pp. 975-978.
Ember, Agoston ; Clark, Jeb S. ; Varjas, Timea ; Kiss, Istvan ; Ember, I. ; Baliga, Radhakrishna ; Arany, Istvan. / The plant-derived natural compound Flavin 7® attenuates oxidative stress in cultured renal proximal tubule cells. In: In Vivo. 2009 ; Vol. 23, No. 6. pp. 975-978.
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