The piglet as a model for B cell and immune system development

J. E. Butler, K. M. Lager, I. Splichal, D. Francis, I. Kacskovics, M. Sinkora, N. Wertz, J. Sun, Y. Zhao, W. R. Brown, R. DeWald, S. Dierks, S. Muyldermans, J. K. Lunney, P. B. McCray, C. S. Rogers, M. J. Welsh, P. Navarro, F. Klobasa, F. Habe & 1 others J. Ramsoondar

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

Original languageEnglish
Pages (from-to)147-170
Number of pages24
JournalVeterinary Immunology and Immunopathology
Volume128
Issue number1-3
DOIs
Publication statusPublished - Mar 15 2009

Fingerprint

B-lymphocytes
immune system
piglets
Immune System
B-Lymphocytes
Swine
neonates
Mothers
swine
Adaptive Immunity
passive immunity
Immunotherapy
Primates
Biomedical Research
Mammals
Immunity
Rodentia
immunotherapy
biomedical research
History

Keywords

  • Developmental immunology
  • Gnotobiotic
  • Models
  • Review
  • Swine

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Butler, J. E., Lager, K. M., Splichal, I., Francis, D., Kacskovics, I., Sinkora, M., ... Ramsoondar, J. (2009). The piglet as a model for B cell and immune system development. Veterinary Immunology and Immunopathology, 128(1-3), 147-170. https://doi.org/10.1016/j.vetimm.2008.10.321

The piglet as a model for B cell and immune system development. / Butler, J. E.; Lager, K. M.; Splichal, I.; Francis, D.; Kacskovics, I.; Sinkora, M.; Wertz, N.; Sun, J.; Zhao, Y.; Brown, W. R.; DeWald, R.; Dierks, S.; Muyldermans, S.; Lunney, J. K.; McCray, P. B.; Rogers, C. S.; Welsh, M. J.; Navarro, P.; Klobasa, F.; Habe, F.; Ramsoondar, J.

In: Veterinary Immunology and Immunopathology, Vol. 128, No. 1-3, 15.03.2009, p. 147-170.

Research output: Contribution to journalArticle

Butler, JE, Lager, KM, Splichal, I, Francis, D, Kacskovics, I, Sinkora, M, Wertz, N, Sun, J, Zhao, Y, Brown, WR, DeWald, R, Dierks, S, Muyldermans, S, Lunney, JK, McCray, PB, Rogers, CS, Welsh, MJ, Navarro, P, Klobasa, F, Habe, F & Ramsoondar, J 2009, 'The piglet as a model for B cell and immune system development', Veterinary Immunology and Immunopathology, vol. 128, no. 1-3, pp. 147-170. https://doi.org/10.1016/j.vetimm.2008.10.321
Butler, J. E. ; Lager, K. M. ; Splichal, I. ; Francis, D. ; Kacskovics, I. ; Sinkora, M. ; Wertz, N. ; Sun, J. ; Zhao, Y. ; Brown, W. R. ; DeWald, R. ; Dierks, S. ; Muyldermans, S. ; Lunney, J. K. ; McCray, P. B. ; Rogers, C. S. ; Welsh, M. J. ; Navarro, P. ; Klobasa, F. ; Habe, F. ; Ramsoondar, J. / The piglet as a model for B cell and immune system development. In: Veterinary Immunology and Immunopathology. 2009 ; Vol. 128, No. 1-3. pp. 147-170.
@article{775fe749ef6f4a9680d7f727b97a6d19,
title = "The piglet as a model for B cell and immune system development",
abstract = "The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.",
keywords = "Developmental immunology, Gnotobiotic, Models, Review, Swine",
author = "Butler, {J. E.} and Lager, {K. M.} and I. Splichal and D. Francis and I. Kacskovics and M. Sinkora and N. Wertz and J. Sun and Y. Zhao and Brown, {W. R.} and R. DeWald and S. Dierks and S. Muyldermans and Lunney, {J. K.} and McCray, {P. B.} and Rogers, {C. S.} and Welsh, {M. J.} and P. Navarro and F. Klobasa and F. Habe and J. Ramsoondar",
year = "2009",
month = "3",
day = "15",
doi = "10.1016/j.vetimm.2008.10.321",
language = "English",
volume = "128",
pages = "147--170",
journal = "Veterinary Immunology and Immunopathology",
issn = "0165-2427",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - The piglet as a model for B cell and immune system development

AU - Butler, J. E.

AU - Lager, K. M.

AU - Splichal, I.

AU - Francis, D.

AU - Kacskovics, I.

AU - Sinkora, M.

AU - Wertz, N.

AU - Sun, J.

AU - Zhao, Y.

AU - Brown, W. R.

AU - DeWald, R.

AU - Dierks, S.

AU - Muyldermans, S.

AU - Lunney, J. K.

AU - McCray, P. B.

AU - Rogers, C. S.

AU - Welsh, M. J.

AU - Navarro, P.

AU - Klobasa, F.

AU - Habe, F.

AU - Ramsoondar, J.

PY - 2009/3/15

Y1 - 2009/3/15

N2 - The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

AB - The ability to identify factors responsible for disease in all species depends on the ability to separate those factors which are environmental from those that are intrinsic. This is particularly important for studies on the development of the adaptive immune response of neonates. Studies on laboratory rodents or primates have been ambiguous because neither the effect of environmental nor maternal factors on the newborn can be controlled in mammals that: (i) transmit potential maternal immunoregulatory factors in utero and (ii) are altricial and cannot be reared after birth without their mothers. Employing the newborn piglet model can address each of these concerns. However, it comes at the price of having first to characterize the immune system of swine and its development. This review focuses on the porcine B cell system, especially on the methods used for its characterization in fetal studies and neonatal piglets. Understanding these procedures is important in the interpretation of the data obtained. Studies on neonatal piglets have (a) provided valuable information on the development of the adaptive immune system, (b) lead to important advances in evolutionary biology, (c) aided our understanding of passive immunity and (d) provided opportunities to use swine to address specific issues in veterinary and biomedical research and immunotherapy. This review summarizes the history of the development of the piglet as a model for antibody repertoire development, thus providing a framework to guide future investigators.

KW - Developmental immunology

KW - Gnotobiotic

KW - Models

KW - Review

KW - Swine

UR - http://www.scopus.com/inward/record.url?scp=60849101054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60849101054&partnerID=8YFLogxK

U2 - 10.1016/j.vetimm.2008.10.321

DO - 10.1016/j.vetimm.2008.10.321

M3 - Article

VL - 128

SP - 147

EP - 170

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

SN - 0165-2427

IS - 1-3

ER -