An in vitro isolated spiral strip of rabbit common bile duct was prepared and tested for its pharmacological reactivity. It was found to be a suitable preparation with a long lasting and stable sensitivity when exposed to various drugs. The pharmacological reactivity proved to var along the common bile duct; the different portions (sphincteric, median and hepatic) displayed different activities to the various agonists and antagonists. The following receptors were identified in different sections: alpha and beta-adrenergic, muscarinic cholinergic, bradykinin, H1 and prostaglandin F2 alpha. Only the sphincteric portion exhibited rhythmic peristalsis; the other portions produced merely small, irregular spontaneous contractions.
|Number of pages||13|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Jan 1 1993|
ASJC Scopus subject areas
- Pharmaceutical Science