The pharmacological reactivity of an isolated circular smooth muscle strip of the rabbit common bile duct

E. Minker, T. Varkonyi, E. Tamaskovits

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Abstract

An in vitro isolated spiral strip of rabbit common bile duct was prepared and tested for its pharmacological reactivity. It was found to be a suitable preparation with a long lasting and stable sensitivity when exposed to various drugs. The pharmacological reactivity proved to var along the common bile duct; the different portions (sphincteric, median and hepatic) displayed different activities to the various agonists and antagonists. The following receptors were identified in different sections: alpha and beta-adrenergic, muscarinic cholinergic, bradykinin, H1 and prostaglandin F2 alpha. Only the sphincteric portion exhibited rhythmic peristalsis; the other portions produced merely small, irregular spontaneous contractions.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalActa pharmaceutica Hungarica
Volume63
Issue number3
Publication statusPublished - Jan 1 1993

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ASJC Scopus subject areas

  • Pharmaceutical Science

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