The pharmacokinetics and metabolism of N-desmethyl-N-formyl-leurosine (F-leuruosine) in the rat

Sarolta Ronai-Lukacs, Laszlo Vereczkey

Research output: Contribution to journalArticle

Abstract

Absorption, tissue distribution, excretion, protein binding, and the metabolism ofl4C labelled F-leurosine were studied in the rat. A triphasic curve for the disappearance of the drug from blood was found. The bile was the major route of excretion: 80% of radioactivity was recovered in the bile during the first 28 h after i.v. administration. 54% of the F-leurosine binds, in the concentration range of 0.1 umol/l-0.5 mmol/1 to plasma proteins. The TLC and HPLC data suggested that the bile of rats administered [14C]-F-leurosine contained either none or only small amount of metabolic products, which were most probably due to chemical decomposition rather then metabolism. Rat liver homogenates did not metabolize [14C] F-leurosine to any detectable extent.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1 1982

Keywords

  • N-desmethyl-N-[C]-formyl-leurosine
  • chemical decomposition
  • pharmacokinetics
  • rat

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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