A kilégzett levego kondenzátumának pH-ja: Új lehetoség a gyulladásos légúti betegségek vizsgálatában

Translated title of the contribution: The pH of the exhaled breath condensate: New method for investigation of inflammatory airway diseases

Balázs Szili, András Bikov, M. Kollai, I. Horváth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Collecting exhaled breath condensate (EBC) has become a frequently used method in respiratory researches to date. Through this method we can sample airway surface liquid non-invasively by streaming the exhaled breath through a cooled chamber and after we examine the fluid deposited on the wall of the condenser. The sample contains several mediators, biomarkers. The pH of the condensate is one of the most important markers measured in the EBC. Measuring the pH is easy, cheap and it is in the optimal range, there is no problem with the detection limit. The uncertainty of the pH assays is derived from the instability of the EBC pH which results from the altering carbon-dioxide concentration. Many articles have been published on EBC pH in different airway diseases. Acidification of the condensates has been described in bronchial asthma (especially in acute exacerbations), chronic obstructive lung disease (COPD). Due to the steroid treatment the pH has increased in both cases. In patients with bronchiectasis, cystic fibrosis and in chronic cough (bronchial asthma, gastro-esophageal reflux, postnasal drip, and unknown origin) the pH of EBC was also lower. Acidification of the airways in different diseases can play a role in the pathomechanism, and its indicator, the EBC pH might help managing patients with airway diseases.

Original languageHungarian
Pages (from-to)1217-1224
Number of pages8
JournalOrvosi Hetilap
Volume148
Issue number26
DOIs
Publication statusPublished - Jul 1 2007

Fingerprint

Chronic Obstructive Pulmonary Disease
Asthma
Bronchiectasis
Gastroesophageal Reflux
Cough
Cystic Fibrosis
Carbon Dioxide
Uncertainty
Limit of Detection
Biomarkers
Steroids
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A kilégzett levego kondenzátumának pH-ja : Új lehetoség a gyulladásos légúti betegségek vizsgálatában. / Szili, Balázs; Bikov, András; Kollai, M.; Horváth, I.

In: Orvosi Hetilap, Vol. 148, No. 26, 01.07.2007, p. 1217-1224.

Research output: Contribution to journalArticle

@article{cccba355975f47d7a361dcaaf6456133,
title = "A kil{\'e}gzett levego kondenz{\'a}tum{\'a}nak pH-ja: {\'U}j lehetos{\'e}g a gyullad{\'a}sos l{\'e}g{\'u}ti betegs{\'e}gek vizsg{\'a}lat{\'a}ban",
abstract = "Collecting exhaled breath condensate (EBC) has become a frequently used method in respiratory researches to date. Through this method we can sample airway surface liquid non-invasively by streaming the exhaled breath through a cooled chamber and after we examine the fluid deposited on the wall of the condenser. The sample contains several mediators, biomarkers. The pH of the condensate is one of the most important markers measured in the EBC. Measuring the pH is easy, cheap and it is in the optimal range, there is no problem with the detection limit. The uncertainty of the pH assays is derived from the instability of the EBC pH which results from the altering carbon-dioxide concentration. Many articles have been published on EBC pH in different airway diseases. Acidification of the condensates has been described in bronchial asthma (especially in acute exacerbations), chronic obstructive lung disease (COPD). Due to the steroid treatment the pH has increased in both cases. In patients with bronchiectasis, cystic fibrosis and in chronic cough (bronchial asthma, gastro-esophageal reflux, postnasal drip, and unknown origin) the pH of EBC was also lower. Acidification of the airways in different diseases can play a role in the pathomechanism, and its indicator, the EBC pH might help managing patients with airway diseases.",
keywords = "Exhaled breath condensate, Inflammatory airway diseases, pH",
author = "Bal{\'a}zs Szili and Andr{\'a}s Bikov and M. Kollai and I. Horv{\'a}th",
year = "2007",
month = "7",
day = "1",
doi = "10.1556/OH.2007.27986",
language = "Hungarian",
volume = "148",
pages = "1217--1224",
journal = "Orvosi Hetilap",
issn = "0030-6002",
publisher = "Akademiai Kiado",
number = "26",

}

TY - JOUR

T1 - A kilégzett levego kondenzátumának pH-ja

T2 - Új lehetoség a gyulladásos légúti betegségek vizsgálatában

AU - Szili, Balázs

AU - Bikov, András

AU - Kollai, M.

AU - Horváth, I.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Collecting exhaled breath condensate (EBC) has become a frequently used method in respiratory researches to date. Through this method we can sample airway surface liquid non-invasively by streaming the exhaled breath through a cooled chamber and after we examine the fluid deposited on the wall of the condenser. The sample contains several mediators, biomarkers. The pH of the condensate is one of the most important markers measured in the EBC. Measuring the pH is easy, cheap and it is in the optimal range, there is no problem with the detection limit. The uncertainty of the pH assays is derived from the instability of the EBC pH which results from the altering carbon-dioxide concentration. Many articles have been published on EBC pH in different airway diseases. Acidification of the condensates has been described in bronchial asthma (especially in acute exacerbations), chronic obstructive lung disease (COPD). Due to the steroid treatment the pH has increased in both cases. In patients with bronchiectasis, cystic fibrosis and in chronic cough (bronchial asthma, gastro-esophageal reflux, postnasal drip, and unknown origin) the pH of EBC was also lower. Acidification of the airways in different diseases can play a role in the pathomechanism, and its indicator, the EBC pH might help managing patients with airway diseases.

AB - Collecting exhaled breath condensate (EBC) has become a frequently used method in respiratory researches to date. Through this method we can sample airway surface liquid non-invasively by streaming the exhaled breath through a cooled chamber and after we examine the fluid deposited on the wall of the condenser. The sample contains several mediators, biomarkers. The pH of the condensate is one of the most important markers measured in the EBC. Measuring the pH is easy, cheap and it is in the optimal range, there is no problem with the detection limit. The uncertainty of the pH assays is derived from the instability of the EBC pH which results from the altering carbon-dioxide concentration. Many articles have been published on EBC pH in different airway diseases. Acidification of the condensates has been described in bronchial asthma (especially in acute exacerbations), chronic obstructive lung disease (COPD). Due to the steroid treatment the pH has increased in both cases. In patients with bronchiectasis, cystic fibrosis and in chronic cough (bronchial asthma, gastro-esophageal reflux, postnasal drip, and unknown origin) the pH of EBC was also lower. Acidification of the airways in different diseases can play a role in the pathomechanism, and its indicator, the EBC pH might help managing patients with airway diseases.

KW - Exhaled breath condensate

KW - Inflammatory airway diseases

KW - pH

UR - http://www.scopus.com/inward/record.url?scp=34548219033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548219033&partnerID=8YFLogxK

U2 - 10.1556/OH.2007.27986

DO - 10.1556/OH.2007.27986

M3 - Article

C2 - 17588855

AN - SCOPUS:34548219033

VL - 148

SP - 1217

EP - 1224

JO - Orvosi Hetilap

JF - Orvosi Hetilap

SN - 0030-6002

IS - 26

ER -